Protein Info for HMPREF1181_RS16410 in Bacteroides stercoris CC31F

Annotation: ATP-dependent Clp protease ATP-binding subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 842 PF02861: Clp_N" amino acids 17 to 67 (51 residues), 53.6 bits, see alignment 1.5e-17 amino acids 97 to 137 (41 residues), 27.3 bits, see alignment 2.5e-09 PF13191: AAA_16" amino acids 214 to 271 (58 residues), 35 bits, see alignment 1.6e-11 PF00004: AAA" amino acids 238 to 369 (132 residues), 49.3 bits, see alignment E=5.3e-16 amino acids 575 to 692 (118 residues), 38.3 bits, see alignment E=1.3e-12 PF17871: AAA_lid_9" amino acids 377 to 477 (101 residues), 107.7 bits, see alignment E=2e-34 PF02151: UVR" amino acids 450 to 484 (35 residues), 27.3 bits, see alignment (E = 1.8e-09) PF07724: AAA_2" amino acids 569 to 742 (174 residues), 233.5 bits, see alignment E=1e-72 PF07728: AAA_5" amino acids 574 to 700 (127 residues), 54.1 bits, see alignment E=1.3e-17 PF00158: Sigma54_activat" amino acids 574 to 679 (106 residues), 30.1 bits, see alignment E=2.8e-10 PF10431: ClpB_D2-small" amino acids 748 to 828 (81 residues), 81.2 bits, see alignment E=3.3e-26

Best Hits

Swiss-Prot: 52% identical to CLPC_STAHJ: ATP-dependent Clp protease ATP-binding subunit ClpC (clpC) from Staphylococcus haemolyticus (strain JCSC1435)

KEGG orthology group: K03696, ATP-dependent Clp protease ATP-binding subunit ClpC (inferred from 91% identity to bhl:Bache_2293)

Predicted SEED Role

"ATP-dependent Clp protease ATP-binding subunit ClpA" in subsystem Proteolysis in bacteria, ATP-dependent

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (842 amino acids)

>HMPREF1181_RS16410 ATP-dependent Clp protease ATP-binding subunit (Bacteroides stercoris CC31F)
MNNQFSQRVSDIITYSKEEANRLRNRYIGPEHLLLGMLRDGGGKAIEILMKLDIDLKQVK
KRIESFLRDAEDDTLLPDADVPLSPMAAKILKMCILEARILKSSTADAEHVLLAILKDGD
NLAATVLEENQVNYQAVFEQLTMQSTNPNAGMGFPEEEEEEDEDMNMSHSSRNAGQGAAS
SAQTASKKSSNDTPVLDNFGTDMTRAAEEGKLDPVVGREREIERLAQILSRRKKNNPVLI
GEPGVGKSAIVEGLALRIVQKKVSRILFDKRVIMLDMASVVAGTKYRGQFEERIRSIINE
LQKNPNVILFIDEIHTIVGAGAAAGSMDAANMLKPALARGEIQCIGATTLDEYRKNIEKD
GALERRFQKVIVEPTTPEETLQILRNIKEKYEDHHNVSYTDEALEACVKLAERYITDRNF
PDKAIDALDEAGSRVHLTNINVPKEIEEQEKLIEDARVLKAEAVKSQNFELAASYRDREK
ELSARLDEMKEEWEVRLKDDRQLVGEEEIANVISMMSGIPVQRMAQAEGLKLAGMKEDLQ
AKVVAQDAAIEKLTKAILRSRVGLKDPNRPIGTFMFLGPTGVGKTHLAKQLAKYMFGSSD
ALIRIDMSEYMEKYTVSRMIGAAPGYVGYEEGGQLTEKVRRKPYSIVLLDEIEKAHPDVF
NILLQVLDEGRLTDNYGRTIDFKNTVIIMTSNIGTRQLKEFGRGVGFAAQARTDDNEYSR
SVIQKALNKTFAPEFLNRLDEIITFDQLSLDAITKIVDIELKGLYERIEAIGYKMVVDDE
AKRFLAAKGYDVQFGARPLKRAIQNYLEDGLSELIVSAGLQPGDTVNVSVDKEKDELSIT
KA