Protein Info for HMPREF1181_RS15445 in Bacteroides stercoris CC31F

Annotation: sugar kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00294: PfkB
  • amino acids 3 to 312 (310 residues), 111.9 bits, E=2e-36

Best Hits

KEGG orthology group: K00874, 2-dehydro-3-deoxygluconokinase [EC: 2.7.1.45] (inferred from 97% identity to bth:BT_0488)

MetaCyc: 56% identical to 2-keto-3-deoxygluconate kinase (Thermotoga maritima)
2-dehydro-3-deoxygluconokinase. [EC: 2.7.1.178, 2.7.1.45]

Predicted SEED Role

"2-dehydro-3-deoxygluconate kinase (EC 2.7.1.45)" in subsystem D-Galacturonate and D-Glucuronate Utilization or D-gluconate and ketogluconates metabolism or Entner-Doudoroff Pathway (EC 2.7.1.45)

MetaCyc Pathways

• superpathway of hexuronide and hexuronate degradation (9/10 steps found)
• 4-deoxy-L-threo-hex-4-enopyranuronate degradation (5/5 steps found)
• D-galacturonate degradation I (5/5 steps found)
• D-fructuronate degradation (4/4 steps found)
• superpathway of β-D-glucuronosides degradation (6/7 steps found)
• Entner-Doudoroff pathway III (semi-phosphorylative) (6/9 steps found)
• 3,6-anhydro-α-L-galactopyranose degradation (4/7 steps found)
• alginate degradation (2/7 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (15/31 steps found)

KEGG Metabolic Maps

• Pentose and glucuronate interconversions
• Pentose phosphate pathway

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.45

Use Curated BLAST to search for 2.7.1.178 or 2.7.1.45

Protein Sequence (341 amino acids)

>HMPREF1181_RS15445 sugar kinase (Bacteroides stercoris CC31F)
MGKKVVTLGEIMLRLSTPGNTRFVQSDSFDVVYGGGEANVAVSCANYGHDAYFVTKLPKH
EIGQSAVNALRKYGVKTDFIARGGDRVGIYYLETGASMRPSKVIYDRAHSAIAEADAADF
DFDAIMEGADWFHWSGITPAISDKAAELTRLACEAAKRHGVTVSVDLNFRKKLWTKEKAQ
SIMKPLMQYVDVCIGNEEDAELCLGFKPDADVEGGKTDAEGYKGIFKAMAKEFGFKYVIS
TLRESFSATHNGWKAMIYNGEEFYESKRYDINPIIDRVGGGDSFSGGIIHGLLTKPNQGA
ALEFAVAASALKHTINGDFNLVSVEEVEALAGGDASGRVQR