Protein Info for HMPREF1181_RS15145 in Bacteroides stercoris CC31F

Annotation: membrane protein insertase YidC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 615 transmembrane" amino acids 6 to 23 (18 residues), see Phobius details amino acids 337 to 353 (17 residues), see Phobius details amino acids 363 to 387 (25 residues), see Phobius details amino acids 438 to 459 (22 residues), see Phobius details amino acids 481 to 505 (25 residues), see Phobius details amino acids 524 to 543 (20 residues), see Phobius details amino acids 549 to 565 (17 residues), see Phobius details TIGR03593: membrane protein insertase, YidC/Oxa1 family, N-terminal domain" amino acids 2 to 343 (342 residues), 74.1 bits, see alignment E=1.6e-24 PF14849: YidC_periplas" amino acids 83 to 352 (270 residues), 115 bits, see alignment E=6.2e-37 TIGR03592: membrane protein insertase, YidC/Oxa1 family" amino acids 366 to 566 (201 residues), 175.2 bits, see alignment E=1.5e-55 PF02096: 60KD_IMP" amino acids 368 to 567 (200 residues), 166.7 bits, see alignment E=4.6e-53

Best Hits

Swiss-Prot: 80% identical to YIDC_BACFR: Membrane protein insertase YidC (yidC) from Bacteroides fragilis (strain YCH46)

KEGG orthology group: K03217, preprotein translocase subunit YidC (inferred from 87% identity to bhl:Bache_2504)

Predicted SEED Role

"Inner membrane protein translocase component YidC, long form"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (615 amino acids)

>HMPREF1181_RS15145 membrane protein insertase YidC (Bacteroides stercoris CC31F)
MDKNTITGLVLIAILLVGFSFLSRPSKEQLAAQQRYYDSIAQVQQREADLKAKAEAALAN
DKEEQTADSTALFFNALQGTDSQVTIQNNLAELTVATKGGRISSATLKEYMGQDKKTPVT
LFSGNDASMNFLFYNKKETIQTENYYFSVVNRTDSTVTMRLAADSASYIDFKYAMHNDTY
LVDFTIDAVGMANKLANTDYVDIEWSQRARQIEKGYTYENRLAELTYKITGDGTDYLSAG
KNDEKEVAERLDWIAFKNQFFSSVFLADANFEKTKLNSKLETQGSGYIKDYSAEMSTAFD
PTGKTPTQLFFYFGPNHYKTLTALDKGRENKWELNRLVYLGWPLIRWINKWFTINIFDWL
SSWGLSMGIVLLLMTLIVKAVVFPATWKTYISSAKMRVLKPKIDEIGKKYPKQEDAMKKQ
QEVMALYSQYGVSPMGGCLPMLIQFPILMALFMFVPSAIELRQQSFLWADDLSTYDAFIN
FPFHIPFLGSHLSLFCLLMTVTNILNTKFMMQQQDTGANPQMAAMKWMSYLMPVMFLFIL
NDYPSGLNYYYFISTLVSVVTTIIMRKMTNEEALLAQLEANRKDPKKMKKTGFAARLEAM
QKQQEQMMKEKQNRK