Protein Info for HMPREF1181_RS14085 in Bacteroides stercoris CC31F

Annotation: adenylosuccinate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00184: adenylosuccinate synthase
  • amino acids 5 to 417 (413 residues), 512.8 bits, E=3.6e-158
• PF00709: Adenylsucc_synt
  • amino acids 5 to 416 (412 residues), 568.6 bits, E=3.7e-175

Best Hits

Swiss-Prot: 93% identical to PURA_BACFN: Adenylosuccinate synthetase (purA) from Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)

KEGG orthology group: K01939, adenylosuccinate synthase [EC: 6.3.4.4] (inferred from 96% identity to bhl:Bache_3159)

Predicted SEED Role

"Adenylosuccinate synthetase (EC 6.3.4.4)" in subsystem CBSS-262719.3.peg.410 or Purine conversions (EC 6.3.4.4)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (38/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (18/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (20/26 steps found)
• superpathway of purine nucleotide salvage (11/14 steps found)
• adenosine ribonucleotides de novo biosynthesis (3/3 steps found)
• superpathway of adenosine nucleotides de novo biosynthesis I (4/5 steps found)
• superpathway of adenosine nucleotides de novo biosynthesis II (5/7 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Biosynthesis of alkaloids derived from histidine and purine
• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.4.4

Protein Sequence (422 amino acids)

>HMPREF1181_RS14085 adenylosuccinate synthase (Bacteroides stercoris CC31F)
MKVDILLGLQWGDEGKGKVVDVLTPRYDVVARFQGGPNAGHTLEFEGQKYVLRSIPSGIF
QGDKVNIIGNGVVLDPALFKAEAEALEASGHNLKERLHISKKAHLILPTHRILDAAYEAA
KGDAKVGTTGKGIGPTYTDKISRNGVRVGDILHDFDKKYAAAKARHEQILKGLNYEYDLS
ELEKVWFEGIEYLKQFKFVDSEHEINGLLSDGKSVLCEGAQGTMLDIDFGSYPFVTSSNT
ICAGACTGLGIAPNKIGEVYGIFKAYCTRVGAGPFPTELFDKTGDQICTLGHEFGSVTGR
KRRCGWIDLVALKYAIMVDGVTKLIMMKSDVLDSFETIKACVAYKVNGEEIDYFPFDIEG
VEPVYVELPGWQTDMTKMQSEDEFPEEFNAYLSFLEEQLGVPVKIVSVGPDREQTIERYT
EE