Protein Info for HMPREF1181_RS13925 in Bacteroides stercoris CC31F

Annotation: ribonuclease Y

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 512 transmembrane" amino acids 6 to 24 (19 residues), see Phobius details PF12072: RNase_Y_N" amino acids 5 to 196 (192 residues), 117.5 bits, see alignment E=1.1e-37 TIGR03319: ribonuclease Y" amino acids 10 to 512 (503 residues), 642.9 bits, see alignment E=3.3e-197 PF00013: KH_1" amino acids 211 to 260 (50 residues), 29.1 bits, see alignment 1.4e-10 TIGR00277: HDIG domain" amino acids 324 to 400 (77 residues), 62 bits, see alignment E=3.9e-21 PF01966: HD" amino acids 329 to 419 (91 residues), 68.6 bits, see alignment E=1.2e-22

Best Hits

Swiss-Prot: 94% identical to RNY_BACFR: Ribonuclease Y (rny) from Bacteroides fragilis (strain YCH46)

KEGG orthology group: K06950, uncharacterized protein (inferred from 98% identity to bhl:Bache_1564)

Predicted SEED Role

"2',3'-cyclic-nucleotide 2'-phosphodiesterase (EC 3.1.4.16)" in subsystem Purine conversions (EC 3.1.4.16)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.1.4.16

Use Curated BLAST to search for 3.1.4.16

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (512 amino acids)

>HMPREF1181_RS13925 ribonuclease Y (Bacteroides stercoris CC31F)
MTVVTIVVSIACFIVGGFASYMFFKHGLKSKYDSILKEAETEAEVIKKNKLLEVKEKFLN
KKADLEKEVSLRNQKIQQAENKLKQRELVLNQRQEEIQRKKLEAEAVKENLEAQLAIVDK
KKEELEHMQRQEIEKLEAISGLSAEEAKERMVESLKEEAKTQAQSYINDIMDDAKLTASK
EAKRIVIQSIQRVATETAIENSVTVFHIESDEIKGRIIGREGRNIRALEAATGVEIVVDD
TPEAIVLSAFDPVRREIARLALHQLVTDGRIHPARIEEVVAKVRKQVEEEIIETGKRTTI
DLGIHGLHPELIRIIGKMKYRSSYGQNLLQHARETANLCAVMASELGLNPKKAKRAGLLH
DIGKVPDEEPELPHALYGMKLAEKFKEKPDICNAIGAHHDEVEMTSLLAPIVQVCDAISG
ARPGARREIVEAYIKRLNDLEQLAMSYPGVTKTYAIQAGRELRVIVGADKIDDKATENLS
GEIAKKIQDEMTYPGQVKITVIRETRAVSYAK