Protein Info for HMPREF1181_RS11880 in Bacteroides stercoris CC31F

Annotation: molecular chaperone DnaK

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 639 TIGR02350: chaperone protein DnaK" amino acids 3 to 597 (595 residues), 956.3 bits, see alignment E=2.8e-292 PF00012: HSP70" amino acids 4 to 597 (594 residues), 858.8 bits, see alignment E=1.8e-262 PF06723: MreB_Mbl" amino acids 114 to 370 (257 residues), 53.8 bits, see alignment E=1.5e-18

Best Hits

Swiss-Prot: 96% identical to DNAK_BACFN: Chaperone protein DnaK (dnaK) from Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)

KEGG orthology group: K04043, molecular chaperone DnaK (inferred from 98% identity to bhl:Bache_1718)

MetaCyc: 63% identical to chaperone protein DnaK (Escherichia coli K-12 substr. MG1655)
Non-chaperonin molecular chaperone ATPase. [EC: 3.6.4.10, 5.6.1.7]

Predicted SEED Role

"Chaperone protein DnaK" in subsystem Heat shock dnaK gene cluster extended or Protein chaperones

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.4.10 or 5.6.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (639 amino acids)

>HMPREF1181_RS11880 molecular chaperone DnaK (Bacteroides stercoris CC31F)
MGKIIGIDLGTTNSCVSVFEGNEPVVIANSEGKRTTPSVVAFVDGGERKIGDPAKRQAIT
NPTRTVFSIKRFMGENWDQVQKEIARVPYKVVKGDNNTPRVDIDGRLYTPQEISAMILQK
MKKTAEDYLGQEVTEAVITVPAYFSDSQRQATKEAGQIAGLEVKRIVNEPTAAALAYGID
KAHKDMKVAVFDLGGGTFDISILEFGGGVFEVLSTNGDTHLGGDDFDQVIIDWLVQEFKN
DEGADLTQDPMAMQRLKEAAEKAKIELSSSTSTEINLPYIMPVGGVPKHLVKTLTRAKFE
ALAHNLIQACLEPCKKAMSDAGLGNSDIDEVILVGGSSRIPAVQKLVEDFFGKVPSKGVN
PDEVVAVGAAVQGAVLTDEIKGVVLLDVTPLSMGIETMGGVMTKLIDANTTIPCKKSETF
STAADNQTEVTIHVLQGERPMAAQNKSIGQFNLTGIAPARRGIPQIEVTFDIDANGILKV
SAKDKATGKEQAIRIEASSGLSKEEIEKMKAEAEANAEADKKEREKVDKLNQADSMIFTT
ENQLKELGDKLPADKKAPIEAALQKLKDAHKAQDLAAVDSAMAELNTAFQAASAEMYAQS
GAQGGAQAGPDMNAGQQGGAQDNGKHGDNVQDADFEEVK