Protein Info for HMPREF1181_RS10845 in Bacteroides stercoris CC31F

Annotation: thiol peroxidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08534: Redoxin
  • amino acids 19 to 162 (144 residues), 109.1 bits, E=1.8e-35
• PF00578: AhpC-TSA
  • amino acids 20 to 145 (126 residues), 68.4 bits, E=5.8e-23

Best Hits

Swiss-Prot: 57% identical to TPX_CHLTE: Thiol peroxidase (tpx) from Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)

KEGG orthology group: K11065, thiol peroxidase, atypical 2-Cys peroxiredoxin [EC: 1.11.1.15] (inferred from 90% identity to bhl:Bache_1902)

MetaCyc: 54% identical to lipid hydroperoxide peroxidase (Escherichia coli K-12 substr. MG1655)
1.11.1.15-RXN [EC: 1.11.1.24]

Predicted SEED Role

"Thiol peroxidase, Tpx-type (EC 1.11.1.15)" in subsystem Thioredoxin-disulfide reductase (EC 1.11.1.15)

KEGG Metabolic Maps

• Glutathione metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.11.1.15

Use Curated BLAST to search for 1.11.1.15 or 1.11.1.24

Protein Sequence (167 amino acids)

>HMPREF1181_RS10845 thiol peroxidase (Bacteroides stercoris CC31F)
MATTKFKGQPVKVIGEFIKVGAVAPDFELVKTDLSSFSLKELNGKNVILNIFPSLDTGVC
AASVRKFNELAAGLPDTVVLAVSKDLPFAHARFCTTEGIENVIPLSDFRCSDFDENYGVR
MADGPLSGLLARAVIVVGKDGKIAYTELVPEITQEPDYEKAIAAVRK