Protein Info for HMPREF1181_RS10795 in Bacteroides stercoris CC31F

Annotation: dipeptide epimerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 389 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details PF02746: MR_MLE_N" amino acids 57 to 167 (111 residues), 37.8 bits, see alignment E=2e-13 PF13378: MR_MLE_C" amino acids 197 to 386 (190 residues), 115 bits, see alignment E=4.1e-37

Best Hits

Swiss-Prot: 82% identical to AEEP_BACTN: L-Ala-D/L-Glu epimerase (BT_1313) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

KEGG orthology group: None (inferred from 88% identity to bhl:Bache_1926)

Predicted SEED Role

"L-alanine-DL-glutamate epimerase" in subsystem Muconate lactonizing enzyme family

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (389 amino acids)

>HMPREF1181_RS10795 dipeptide epimerase (Bacteroides stercoris CC31F)
MQNRRDFLKTAAFAALGSGMAINSVLAGEGAAPALFNINKSGVTPKMKLRFFSYELRLRH
VFTVAAYSRTTTPDVQVEIEYDGIIGYGEASMPPYLQHELGTMDSVLAFLKKVQDVIGQF
SDPFRLEDILSYIDSLSAGDSAAKTAVDIALHDLVGKLLQVPWYKIWGLDKEKAPSTTFT
IGIDTPDVVREKTKECAGQFNILKVKLGRDNDKEMIETIRSVTDLPIAIDANQGWKDKHY
ALDMIHWLKEKGIVMIEQPMPKEQLDDIAWVTGQSPLPVFADESVQRLKDIVGLKDAFTG
INIKLMKCTGMREAWKMVTLARALGMKVMVGCMTETSCAISAAAQFSPAVDFADLDGSLL
IANDRFKGMEVVKGKITLPDLPGIGVVKI