Protein Info for HMPREF1181_RS10540 in Bacteroides stercoris CC31F

Annotation: cobyrinate a,c-diamide synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF13500: AAA_26
  • amino acids 6 to 186 (181 residues), 42.8 bits, E=8.3e-15
• TIGR00379: cobyrinic acid a,c-diamide synthase
  • amino acids 8 to 401 (394 residues), 285.6 bits, E=3.6e-89
• PF01656: CbiA
  • amino acids 8 to 183 (176 residues), 63.5 bits, E=2.9e-21
• PF07685: GATase_3
  • amino acids 254 to 450 (197 residues), 91.4 bits, E=9.1e-30

Predicted SEED Role

"Cobyrinic acid A,C-diamide synthase" in subsystem Cobalamin synthesis or Coenzyme B12 biosynthesis

MetaCyc Pathways

• cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion) (12/15 steps found)
• adenosylcobalamin biosynthesis I (anaerobic) (24/36 steps found)

Protein Sequence (458 amino acids)

>HMPREF1181_RS10540 cobyrinate a,c-diamide synthase (Bacteroides stercoris CC31F)
MRRVSQFLIAAPTSGSGKTTVSRGLMALLTQKGLAVQPFKCGPDYIDTKYHTAVCGRASI
NLDTFMASGEHVCELYAHHAVSADVCIVEGMMGMFDGYDRDRGSSAEITQLLQLPVVLVV
DAKSAAYSMAPLLSGFIHFRPDIRIAGVIFNRVGSSRHYEMLREVCAEVGITCLGYLPKE
KMLEQESRYLGLDFSRSKGTDAIGTLTRLLEQCVDWKLLLAKTAVPLRETRERDKEFVGG
RKPGNLRILVARNEESFSFIYEEHLEMLRGMGRISFFDPEKDVPIAQDTDLLYLPGGYPE
KHSMALAGARQVKESVREYIERGGKTLAECGGMIYLSYAIGYDKREHESGGSGFDRMAGV
FPFYISNESEYRKLTLGYRSFDYKGQRLRGHEFHYTQFGKSGTAPDDSKKELYMPPTVVQ
VYNAKGQPVNTPVFRYKNTIASYTHLYWGETDIMRLFE