Protein Info for HMPREF1181_RS10070 in Bacteroides stercoris CC31F

Annotation: family 20 glycosylhydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 778 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF02838: Glyco_hydro_20b" amino acids 28 to 158 (131 residues), 83.2 bits, see alignment E=6.6e-27 PF00728: Glyco_hydro_20" amino acids 162 to 512 (351 residues), 413.6 bits, see alignment E=2.1e-127 PF13290: CHB_HEX_C_1" amino acids 558 to 611 (54 residues), 50 bits, see alignment 6e-17 PF13287: Fn3_assoc" amino acids 561 to 611 (51 residues), 49.8 bits, see alignment 7.6e-17

Best Hits

KEGG orthology group: K12373, hexosaminidase [EC: 3.2.1.52] (inferred from 51% identity to pdi:BDI_2521)

Predicted SEED Role

"Beta-hexosaminidase (EC 3.2.1.52)" in subsystem Chitin and N-acetylglucosamine utilization or N-Acetyl-Galactosamine and Galactosamine Utilization (EC 3.2.1.52)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.52

Use Curated BLAST to search for 3.2.1.52

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (778 amino acids)

>HMPREF1181_RS10070 family 20 glycosylhydrolase (Bacteroides stercoris CC31F)
MNKLIRFVVLPALCLLMGCAKPQEVISYSVVPMPQEVKLTEEKPFCLNENTVVTYPAGNP
LLKRNAEFLSEYISQSLPFTLPVQELEEGHTAKHAIVLTLNSTISNKEGYRLSVTEEGVV
IEGQTAQGVFYGIQTLRKSLSALAESKSVLLPSAVVDDEPRFTYRGMHLDVCRHFFSVEF
VKEYIDLLALHNMNTFHWHLTDDQGWRIESKKYPKLTEVGSVRYRTVVGYLGSGIYDHTE
YGGYYTQEQMKEVVAYAAERYINVVPEIDLPGHTLAVLASYPEFGCTGGPYEVCPDWGVF
PDVLCIGNEQTMEFVEDILGELIEIFPSKYIHIGGDEAPRTRWKKCPKCQKRIADEGLKA
RGGYTAEDRLQSYCMQRAEHFLNSHGRSVIGWDEILNGDIAPNAIVMSWQGTVGGIKAAQ
MGHDVIMTPNTHCYFDFYQTGDTRNEPLAIGGCLPVSKVYELEPTAGLTDKQAKHILGVQ
ANLWTEYITTTEHVEYMVLPRMAALAEVQWTAAKQKDYRNFQKRVVHLMKLYHKNRWNYA
RHLYDLHANFQPDMEKRQINVTLDVIDDAPIYYTLDGSEPTSFSTCYTDTFHIDKSVQLR
AVAIRPDGKNSGLEESVSFNKATLCPIRFLSAEPYPNYTFGGAVTLVDGRVGNENFATGA
WLGFVGEEVSLLIDLQQPTEISRLSLNAMTYMDAWIMAPTAVMVSVSDNNKKFVPIVSKQ
YPVDTDTRKRCISTYDLNFNAVTTRYVKLSVQPSPTLPVGHSAEGKIPFLFMDEIAIF