Protein Info for HMPREF1181_RS09575 in Bacteroides stercoris CC31F

Annotation: thymidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00265: TK
  • amino acids 16 to 188 (173 residues), 188.6 bits, E=4.5e-60

Best Hits

Swiss-Prot: 91% identical to KITH_BACFN: Thymidine kinase (tdk) from Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)

KEGG orthology group: K00857, thymidine kinase [EC: 2.7.1.21] (inferred from 93% identity to bhl:Bache_1176)

MetaCyc: 51% identical to thymidine kinase monomer (Bacillus anthracis)
Deoxynucleoside kinase. [EC: 2.7.1.145, 2.7.1.21]; 2.7.1.145,2.7.1.21 [EC: 2.7.1.145, 2.7.1.21]

Predicted SEED Role

"Thymidine kinase (EC 2.7.1.21)" in subsystem Folate Biosynthesis (EC 2.7.1.21)

MetaCyc Pathways

• pyrimidine deoxyribonucleosides salvage (4/5 steps found)
• superpathway of pyrimidine deoxyribonucleoside salvage (5/9 steps found)
• purine deoxyribonucleosides salvage (2/6 steps found)

KEGG Metabolic Maps

• Drug metabolism - other enzymes
• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.145 or 2.7.1.21

Protein Sequence (201 amino acids)

>HMPREF1181_RS09575 thymidine kinase (Bacteroides stercoris CC31F)
MVLFSEDHIQETKRRGRIEVICGSMFSGKTEELIRRLKRAKFAKQRVEIYKPAIDTRYSE
ADVVSHDSNIISSTPIDSSASILLFTSEIDVVGIDEAQFFDEGLIDVCNQLANNGIRVIV
AGLDMDFRGNPFGPMPGLCAIADEVSKVHAICVKCGQLASFSHRTVKNDKQVLLGETAEY
EPLCRECYLRAIKEDQQTASD