Protein Info for HMPREF1181_RS09365 in Bacteroides stercoris CC31F

Annotation: DNA polymerase III subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1265 PF02811: PHP" amino acids 6 to 222 (217 residues), 169.3 bits, see alignment E=1.9e-53 TIGR00594: DNA polymerase III, alpha subunit" amino acids 388 to 1138 (751 residues), 841.9 bits, see alignment E=4.1e-257 PF07733: DNA_pol3_alpha" amino acids 400 to 668 (269 residues), 292.8 bits, see alignment E=5.4e-91 PF17657: DNA_pol3_finger" amino acids 671 to 834 (164 residues), 186.7 bits, see alignment E=4.1e-59 PF14579: HHH_6" amino acids 907 to 996 (90 residues), 102.1 bits, see alignment 3.1e-33

Best Hits

KEGG orthology group: K02337, DNA polymerase III subunit alpha [EC: 2.7.7.7] (inferred from 95% identity to bhl:Bache_1219)

Predicted SEED Role

"DNA polymerase III alpha subunit (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1265 amino acids)

>HMPREF1181_RS09365 DNA polymerase III subunit alpha (Bacteroides stercoris CC31F)
MQDFVHLHVHTQYSLLDGQASVSRLVDKAMKDGMKGIAVTDHGNMFGIKEFTNYVNKKNS
GPKGEIKDLKKRIAGIESGEIECEDKEAEIAACRAKITEAENKLFKPIIGCEMYVARRTM
DKKEGKPDQSGYHLIVLAKNEKGYHNLIKLVSRAWTMGYYMRPRTDRNELEKYHEGLIVC
SACIGGEVPKKIINDQLEEAEEAIRWYKNLFGDDYYLELQRHKATVSRANHEAYPLQQKA
NAKLLEYARKYNIKVICSNDVHFVDEENAEAHDRLICLSTGKDLDDPSRMLYTKQEWMKT
KAEMNELFADVPEALSNTLEILDKVEYYSIDHAPIMPTFAIPEDFGTEEEYRRKYTEKDL
FDEFTQDENGNVVLDEEAAKAKIKRLGGYEKLYRIKLEADYLAKLAFDGAKRLYGDPLSD
EVKERLVFELYIMKTMGFPGYFLIVQDFINAARTQLGVSVGPGRGSAAGSAVAYCLGITK
IDPIQYDLLFERFLNPDRISLPDIDVDFDDDGRGEVLRWVTEKYGQEKVAHIITYGTMAT
KLAIKDVARVQKLPLSESDRLAKLVPDKIPDKKLNLPNAIAYVPELQAAEASPDPLVRDT
LKYAKMLEGNVRGTGVHACGTIICRDDITDWVPVSTADDKETGEKMLVTQYEGSVIEDTG
LIKMDFLGLKTLSIIKEAVENVRLHRGLSLDIDKISIKDPATYKLYCDGRTIGTFQFESA
GMQKYLRELQPSTFEDLIAMNALYRPGPMDYIPDFIDRKWGRKPIEYDIPIMEKYLKDTY
GITVYQEQVMLLSRLLADFTRGESDALRKAMGKKLRDKLDHMKPKFIAGGQKNGHDAKVL
EKIWADWEKFASYAFNKSHATCYSWVAYQTAFLKANYPAEYMAAVMSRSLSDITTITKLM
DECKSMGIKVLGPDVNESNLKFTVNPEGNIRFGLGAVKGVGEGAVQSIMEERAKNGPYTG
IFDFVQRVNLNACNKKNLECLALAGGFDSFPELKREQYFAVNTKNEVFIETLVRYGNRYQ
ADKAAAVNSLFGGENVVDIATPEIPQAERWSDLDRLNKERDLVGIYLSAHPLDEYAVVLE
YVCNTHMAELEDKTALVGREITMGGIVTSVRRGISKNGNPYGIAKIEDYSGSAELPFFGN
DWVTYQGYLGERTFLYIKARCQPKQWRQDELELKITSMELLPDVKEKLIEKITILIPLGV
LNKALVTELAELTKERPGTTELYFKVTDPESKMTLDLVSRPVKLSVGRELISYLKERPEL
DFRIN