Protein Info for HMPREF1181_RS09040 in Bacteroides stercoris CC31F

Annotation: NADH-quinone oxidoreductase subunit M

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01972: proton-translocating NADH-quinone oxidoreductase, chain M
  • amino acids 4 to 488 (485 residues), 419.5 bits, E=8.7e-130
• PF00361: Proton_antipo_M
  • amino acids 130 to 409 (280 residues), 218.3 bits, E=7.1e-69

Best Hits

KEGG orthology group: K00342, NADH dehydrogenase I subunit M [EC: 1.6.5.3] (inferred from 94% identity to bhl:Bache_1292)

Predicted SEED Role

"NADH-ubiquinone oxidoreductase chain M (EC 1.6.5.3)" in subsystem Respiratory Complex I (EC 1.6.5.3)

MetaCyc Pathways

• aerobic respiration III (alternative oxidase pathway) (2/3 steps found)
• NADH to cytochrome bd oxidase electron transfer I (1/2 steps found)
• NADH to cytochrome bo oxidase electron transfer I (1/2 steps found)
• aerobic respiration I (cytochrome c) (2/4 steps found)
• NAD(P)/NADPH interconversion (2/6 steps found)
• Fe(II) oxidation (1/6 steps found)

KEGG Metabolic Maps

• Oxidative phosphorylation

Isozymes

Compare fitness of predicted isozymes for: 1.6.5.3

Use Curated BLAST to search for 1.6.5.3

Protein Sequence (495 amino acids)

>HMPREF1181_RS09040 NADH-quinone oxidoreductase subunit M (Bacteroides stercoris CC31F)
MNFLSIFVLIPLLMLLGLWLSRNIAQIRAVMVAGASALLVAAVGLTVVYLQARHGGATDE
MLFRADVAWYPALNIHYSVGVDGISVAMLLLSAIIVFTGTFASWRLQPLTKEYFLWFTLL
SMGVFGFFISTDLFTMFMFYEVALIPMYLLIGVWGSGRKEYAAMKLTLMLMGGSAFLLIG
ILGIYFGSGATTMNLLEIAQLHNIPVEQQRIWFPLTFLGFGVLGALFPFHTWSPDGHASA
PTAVSMLHAGVLMKLGGYGCFRIAMYLMPEAAQELGWIFLVLTGISVVYGAFSACVQTDL
KYINAYSSVSHCGLVLFAILMMNRTACTGAVLQMLSHGLMTALFFALIGMIYGRTHTRDV
RELSGLMKIMPFLAVSYVIAGLANLGLPGLSGFIAEMTIFNGAFQHPDTFHRAWTVIACT
SIVITAVYILRLVGKILYGTCTNKHHLTLTDATWDERTAVIILIACVAGLGLAPLWISNM
IGDSVLPVVNLLATH