Protein Info for HMPREF1181_RS09010 in Bacteroides stercoris CC31F

Annotation: NADH-quinone oxidoreductase subunit D

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00329: Complex1_30kDa
  • amino acids 5 to 133 (129 residues), 119 bits, E=1.9e-38
• PF00346: Complex1_49kDa
  • amino acids 285 to 453 (169 residues), 205.1 bits, E=1.2e-64
  • amino acids 455 to 530 (76 residues), 69.3 bits, E=3e-23

Best Hits

Swiss-Prot: 86% identical to NUOCD_BACFN: NADH-quinone oxidoreductase subunit C/D (nuoC) from Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)

KEGG orthology group: K13378, NADH dehydrogenase I subunit C/D [EC: 1.6.5.3] (inferred from 91% identity to bhl:Bache_1298)

Predicted SEED Role

"NADH-ubiquinone oxidoreductase chain C (EC 1.6.5.3) / NADH-ubiquinone oxidoreductase chain D (EC 1.6.5.3)" in subsystem Respiratory Complex I (EC 1.6.5.3)

MetaCyc Pathways

• aerobic respiration III (alternative oxidase pathway) (2/3 steps found)
• NADH to cytochrome bd oxidase electron transfer I (1/2 steps found)
• NADH to cytochrome bo oxidase electron transfer I (1/2 steps found)
• aerobic respiration I (cytochrome c) (2/4 steps found)
• NAD(P)/NADPH interconversion (2/6 steps found)
• Fe(II) oxidation (1/6 steps found)

KEGG Metabolic Maps

• Oxidative phosphorylation

Isozymes

Compare fitness of predicted isozymes for: 1.6.5.3

Use Curated BLAST to search for 1.6.5.3

Protein Sequence (530 amino acids)

>HMPREF1181_RS09010 NADH-quinone oxidoreductase subunit D (Bacteroides stercoris CC31F)
MEIRYIEPAALHDEMLRLRQEEQMDFLECLTGMDWGEPDAAKDTPDTPRGLGVVYQLEST
VTGKRTAIRTATLNREHPELPSVCDIWKAADFLEREVFDFYGVVFVGHPDMRRLYLRNDW
VGHPMRKDDDPEAQNPLRMDNEETVDTTTELELNPDGTVKNKETQLFGDDEYVVNIGPQH
PATHGVMRFRVSLEGEIIKKIDANCGYIHRGIEKMCESLTYPQTLALTDRLDYLGAHQNR
HALCMCIEKAMGIEVSERVQYIRTIMDELQRIDSHLLFYSCLAMDLGALTAFFYGFRDRE
KILDIFEGTCGGRLIMNYNTIGGVQADIAPDFQKKVKEFIPYLRGILHEYHDVFTGNIIA
QQRLKGVGVLSREDAIAFGATGGTGRASGWACDVRKRMPYGVYDKVDFKEIVRTEGDSWA
RYLIRMDEIMESLKIIEQLIDNIPEGAYQEKMKPIIRVPEGTYYAAVEGSRGEFGVFLES
HGDKTPYRLHFRSTGLPLVSTVDTICRGAKIADLIAIGGTLDYVVPDIDR