Protein Info for HMPREF1181_RS08560 in Bacteroides stercoris CC31F

Annotation: MATE family efflux transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 449 transmembrane" amino acids 19 to 36 (18 residues), see Phobius details amino acids 42 to 60 (19 residues), see Phobius details amino acids 65 to 85 (21 residues), see Phobius details amino acids 97 to 119 (23 residues), see Phobius details amino acids 139 to 160 (22 residues), see Phobius details amino acids 170 to 191 (22 residues), see Phobius details amino acids 197 to 217 (21 residues), see Phobius details amino acids 237 to 262 (26 residues), see Phobius details amino acids 274 to 295 (22 residues), see Phobius details amino acids 322 to 341 (20 residues), see Phobius details amino acids 361 to 382 (22 residues), see Phobius details amino acids 394 to 414 (21 residues), see Phobius details amino acids 419 to 442 (24 residues), see Phobius details PF01554: MatE" amino acids 25 to 186 (162 residues), 103.7 bits, see alignment E=8.3e-34 amino acids 257 to 399 (143 residues), 74.8 bits, see alignment E=6.5e-25 TIGR00797: MATE efflux family protein" amino acids 25 to 420 (396 residues), 198.3 bits, see alignment E=9.6e-63 PF14667: Polysacc_synt_C" amino acids 140 to 294 (155 residues), 34.5 bits, see alignment E=2.1e-12

Best Hits

KEGG orthology group: None (inferred from 89% identity to bhl:Bache_3337)

Predicted SEED Role

"Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (449 amino acids)

>HMPREF1181_RS08560 MATE family efflux transporter (Bacteroides stercoris CC31F)
MAGQKTPTALGTENIGKLLMQYAVPAIIAMTASSLYNMVDSIFIGHGVGTMAISGLALTF
PLMNLAAAFGSLVGVGAATLISVKLGQKDYDTAQRVLGNVFVLNILLGVAFTVVVMAFLD
PILYFFGGSDETVGYARDYMQIILLCNAVTHLYLGLNAVLRSSGHPQKAMYATIATVIIN
TILDPVFIYGFGWGIRGAAIATIVAQVISLIWQLRIFSNKDELLHFHRGIFRLKRKIVFD
SLAIGMSPFLMNMAACFIVILINQGLKKYGGDLAIGAFGIVNRLVFIIVMIVMGLNQGMQ
PIAGYNFGAGQHARVIKTLKLTIIYATCVTTFGFIVGMLFSDWVVSIFTSDAELIALSAK
GLRIVVMFFPIIGFQMVTANFFQSIGMASKAIFLSLTRQMMVLLPCLIILPRFFGVAGVW
YSMPISDLLASLIAGTMLVWQLRKFKAQA