Protein Info for HMPREF1181_RS06695 in Bacteroides stercoris CC31F

Annotation: heparinase II/III family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 709 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF16889: Hepar_II_III_N" amino acids 49 to 406 (358 residues), 366.4 bits, see alignment E=1.7e-113 PF07940: Hepar_II_III" amino acids 421 to 617 (197 residues), 102.6 bits, see alignment E=2.6e-33

Best Hits

Swiss-Prot: 61% identical to HEPC_BACTN: Heparin-sulfate lyase (hepC) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

KEGG orthology group: None (inferred from 61% identity to bth:BT_4662)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (709 amino acids)

>HMPREF1181_RS06695 heparinase II/III family protein (Bacteroides stercoris CC31F)
MKNTLFICLFAMFALSGCVDDEEEFATGGNISPELTPENKENAVLNTAVFDQLNLDYPGL
EKVKQYHEAGEDYLAASALLEYYRTRTNVINPNLSLVDVTYSDADLSKANYALEYRFYVN
GQLEDPAIGKPYSVGKAGAINWANNPKGTSAEYQKQLHRHQWFIPQAKVYRGTHDEKYIN
SWIEVYGDWIVQNPKPEAGPIDEGPWWQLQVATRVLDQVQLLDYYKTSSNFTPEWLTTFL
VSFAEQADFLQAYPYKSGGNILITQANALATAGTLMPEFKNAENWKNKGNEILNTEIQQF
LADGWHKEFSLHYHIGVIDNFYEAMKLANANGQSVEFKDALRKAVEVVMHFTYPNFFAKG
SSSDSEEKLDQIVPMFNDSWNKTRSILTKNFKKYSEMFPESDELKYMATSGNGGASQGNT
PGNEMKLFEDAGFYIMRNGWVPESTVMIFSNNKFNDESTSFASYSHNQPDNGTFELYINE
RNFFPDSGVCAYESSDKTIQGYRNWHRKTMHHNTLTLDDWNCEKADGKLLQSETKGNVET
LVFENQSYPNMRHRRAVFYVNKEFFVLVDEGIGSAAGSANLSFNLCRYESEVEYDANEMG
AHTTFTDNNIVVRTFTNETATFNEMEGRVAYVVKNDVFDKRKAYQIKINKLANKTARFIT
VIYPCKKTEGQTIEAVFTDNGYSANGASIKVTINGIEYPLSYILQSNNF