Protein Info for HMPREF1181_RS06425 in Bacteroides stercoris CC31F

Annotation: threonylcarbamoyl-AMP synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 204 TIGR00057: tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family" amino acids 7 to 200 (194 residues), 177.2 bits, see alignment E=1.2e-56 PF01300: Sua5_yciO_yrdC" amino acids 21 to 197 (177 residues), 157.8 bits, see alignment E=1.1e-50

Best Hits

Swiss-Prot: 38% identical to Y1198_HAEIN: Uncharacterized protein HI_1198 (HI_1198) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K07566, putative translation factor (inferred from 88% identity to bhl:Bache_1357)

Predicted SEED Role

"TsaC protein (YrdC domain) required for threonylcarbamoyladenosine t(6)A37 modification in tRNA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (204 amino acids)

>HMPREF1181_RS06425 threonylcarbamoyl-AMP synthase (Bacteroides stercoris CC31F)
MLLKLYEKNNNPADLQQVIDILNDGGIIIYPTDTMYAIGCHGLKERAIERICQLKNTDPK
KNNLSIICYDLSSISEYAKFDNNTFKLMKRNLPGAFTFILNGTVRLPKIFRNRKEVGIRM
PDHPIIRELARLLDAPIMTATLPHNENEDIEYCTDPELIDEKFGNIVDLVIDGGIGGIEG
STVVDCTGGEAEIVRQGKGWLDEG