Protein Info for HMPREF1181_RS04755 in Bacteroides stercoris CC31F
Annotation: tryptophanase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 82% identical to BELY_TRIVA: Probable beta-eliminating lyase (TVAG_054490) from Trichomonas vaginalis
KEGG orthology group: K01667, tryptophanase [EC: 4.1.99.1] (inferred from 91% identity to bth:BT_1492)MetaCyc: 52% identical to tryptophanase subunit (Symbiobacterium thermophilum)
Tryptophanase. [EC: 4.1.99.1]
Predicted SEED Role
"Tryptophanase (EC 4.1.99.1)" in subsystem Aromatic amino acid degradation (EC 4.1.99.1)
MetaCyc Pathways
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (12/15 steps found)
- L-serine degradation (3/3 steps found)
- L-tryptophan degradation II (via pyruvate) (3/3 steps found)
- D-serine degradation (2/3 steps found)
- L-cysteine degradation II (2/3 steps found)
- glycine betaine degradation III (4/7 steps found)
- L-methionine biosynthesis II (3/6 steps found)
- felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis (2/5 steps found)
- L-mimosine degradation (4/8 steps found)
- glycine betaine degradation I (4/8 steps found)
- glutathione-mediated detoxification I (2/8 steps found)
- purine nucleobases degradation II (anaerobic) (12/24 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 4.1.99.1
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (457 amino acids)
>HMPREF1181_RS04755 tryptophanase (Bacteroides stercoris CC31F) MELPFAESWKIKMVEPIRKSTRQEREQWLKEAHYNVFQLKSEQVYIDLITDSGTGAMSDR QWAGIMLGDESYAGASSFFKLKEVITRLTGFEYVIPTHQGRAAENVLFSYLVHEGDIIPG NSHFDTTKGHIESRKAIALDCTIDEARQTQLEIPFKGNVDPAKLEKALQEHHSRIPFIIV TITNNTAGGQPVSMQNLREVRNIADKYNKPVIFDSARFAENAYFIKTREEGYQDKSIKEI TKEMFALADGMTMSAKKDGIVNMGGFIATRRQDWYEGAKGFCVQFEGYLTYGGMNGRDMN ALAIGLDENTEFNNLETRIRQIEYLAKKLDEYGIPYQRPAGGHAIFVDAPKVLTHVPKEE FPAQTLTVELYLEAGIRGCEIGYLLADRDPVTRENRFNGLDLLRLAIPRRVYTDNHMNVI AAALKNVYDRRETITRGVRITWEAPLMRHFTVQLERL