Protein Info for HMPREF1181_RS03190 in Bacteroides stercoris CC31F

Annotation: CidA/LrgA family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 112 signal peptide" amino acids 5 to 6 (2 residues), see Phobius details transmembrane" amino acids 7 to 23 (17 residues), see Phobius details amino acids 30 to 48 (19 residues), see Phobius details amino acids 56 to 77 (22 residues), see Phobius details amino acids 83 to 104 (22 residues), see Phobius details PF03788: LrgA" amino acids 13 to 104 (92 residues), 103.5 bits, see alignment E=2.5e-34

Best Hits

Swiss-Prot: 37% identical to YOHJ_SHIF8: UPF0299 membrane protein YohJ (yohJ) from Shigella flexneri serotype 5b (strain 8401)

KEGG orthology group: K06518, holin-like protein (inferred from 95% identity to bfr:BF0474)

Predicted SEED Role

"Antiholin-like protein LrgA" in subsystem Murein hydrolase regulation and cell death

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (112 amino acids)

>HMPREF1181_RS03190 CidA/LrgA family protein (Bacteroides stercoris CC31F)
MIRQCAILFGCLALGELIVFLTGIKLPSSIIGMLLLTLFLKLGWIKLHWVQGMSDFLVAN
LGFFFIPPGVALMLYFDIIAAEFWPIAIASLVSTLLVLVVTGWVHQLTRKIK