Protein Info for HMPREF1181_RS01800 in Bacteroides stercoris CC31F

Annotation: L-aspartate oxidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00551: L-aspartate oxidase
  • amino acids 4 to 519 (516 residues), 533.5 bits, E=2.5e-164
• PF00890: FAD_binding_2
  • amino acids 6 to 391 (386 residues), 298.9 bits, E=1.1e-92
• PF02910: Succ_DH_flav_C
  • amino acids 440 to 520 (81 residues), 50.4 bits, E=3.3e-17

Best Hits

Swiss-Prot: 48% identical to NADB_YERPE: L-aspartate oxidase (nadB) from Yersinia pestis

KEGG orthology group: K00278, L-aspartate oxidase [EC: 1.4.3.16] (inferred from 95% identity to bhl:Bache_0723)

MetaCyc: 47% identical to L-aspartate oxidase (Escherichia coli K-12 substr. MG1655)
1.5.98.-; L-aspartate oxidase. [EC: 1.4.3.16]

Predicted SEED Role

"L-aspartate oxidase (EC 1.4.3.16)" in subsystem NAD and NADP cofactor biosynthesis global or NAD regulation (EC 1.4.3.16)

MetaCyc Pathways

• NAD de novo biosynthesis I (6/6 steps found)
• NAD de novo biosynthesis IV (anaerobic) (6/6 steps found)
• aspartate superpathway (19/25 steps found)
• nicotine biosynthesis (3/9 steps found)
• superpathway of nicotine biosynthesis (4/12 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Nicotinate and nicotinamide metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.3.16

Protein Sequence (523 amino acids)

>HMPREF1181_RS01800 L-aspartate oxidase (Bacteroides stercoris CC31F)
MVRKFDFLVIGSGIAGMSFALKVAHKGTVALICKAGLEEANTYFAQGGIASVTNLAVDNF
DKHIEDTMIAGDWISDRAAVEKVVRNAPGQISELIKWGVNFDKKDNGEFDLHKEGGHSEF
RILHHKDNTGAEIQESLIEAVKQHPNITVFTNFFAVEIITQHHLGIIVTRYTPGIKCYGA
YVLNENTGEVDTFLSKVTIMATGGCEAVYRNTTNPLVATGDGIAMVYRAKGAVKDMEFIQ
FHPTALYHPGDRPCFLITEAMRGYGGVLRTMDGKEFMQKYDPRLSLAPRDIVARAIDNEM
KQRGDEHVYLDVTHKDPEETKKHFPNIYKKCLSIGIDITKDYIPVAPAAHYLCGGIKVDL
DGQSSIRRLYAIGECSCTGLHGGNRLASNSLIEAVVYADAAAKHALSVLERYDFNEDIPE
WNDEGTISNEERVLITQSMKEVNQIMESYVGIVRSNTRLTRAWNRLDILYEETEKLFKSS
KATRELCELRNMINVGYLITRQAMERKESRGLHYTIDYPHPQK