Protein Info for HMPREF1181_RS01145 in Bacteroides stercoris CC31F

Annotation: 2-oxoacid:ferredoxin oxidoreductase subunit beta

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02775: TPP_enzyme_C
  • amino acids 49 to 196 (148 residues), 98.8 bits, E=1.4e-32

Best Hits

KEGG orthology group: K00175, 2-oxoglutarate ferredoxin oxidoreductase subunit beta [EC: 1.2.7.3] (inferred from 88% identity to bvu:BVU_0978)

Predicted SEED Role

"2-oxoglutarate oxidoreductase, beta subunit (EC 1.2.7.3)" (EC 1.2.7.3)

MetaCyc Pathways

• TCA cycle V (2-oxoglutarate synthase) (7/9 steps found)
• reductive TCA cycle I (8/11 steps found)
• incomplete reductive TCA cycle (5/7 steps found)
• TCA cycle VI (Helicobacter) (6/9 steps found)
• TCA cycle VII (acetate-producers) (6/9 steps found)
• reductive TCA cycle II (7/12 steps found)
• Methanobacterium thermoautotrophicum biosynthetic metabolism (19/56 steps found)

KEGG Metabolic Maps

• Citrate cycle (TCA cycle)
• Reductive carboxylate cycle (CO2 fixation)

Isozymes

Compare fitness of predicted isozymes for: 1.2.7.3

Use Curated BLAST to search for 1.2.7.3

Protein Sequence (334 amino acids)

>HMPREF1181_RS01145 2-oxoacid:ferredoxin oxidoreductase subunit beta (Bacteroides stercoris CC31F)
MCEYTAKDFKKGQPRWCPGCGDHFFLASLHKAMAEIGVPPYKTAVISGIGCSSRLPHYMN
TYGMNTIHGRAAAIATGCKVANPELTVWQVSGDGDGLAIGGNHFIHANRRNINLNMILLN
NRIYGLTKGQYSPTSPRGFVSKSSPYGTVEDPFHPAELCFGARGHFFARAVATDAAGTVE
ILKAAYNHKGASVCEILQNCVIFNNGTHDAVAKKEDRAKHAIYLEHGKPMLFGENNEYGL
MQEGFGLKVVKLGENGITEKDILIHDAHCEDNTLQLKLALMEGPDFPIALGVIRDVEAPT
YDDAVHAQIEEVSAKKKYHNFEELLMTNDTWEVK