Protein Info for HMPREF1181_RS00990 in Bacteroides stercoris CC31F

Annotation: efflux RND transporter periplasmic adaptor subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 342 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 38 to 333 (296 residues), 110.3 bits, see alignment E=4.9e-36 PF16576: HlyD_D23" amino acids 48 to 262 (215 residues), 130.6 bits, see alignment E=5.1e-42 PF13437: HlyD_3" amino acids 160 to 260 (101 residues), 46.5 bits, see alignment E=5.4e-16

Best Hits

KEGG orthology group: None (inferred from 37% identity to dfe:Dfer_1812)

Predicted SEED Role

"Probable Co/Zn/Cd efflux system membrane fusion protein" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (342 amino acids)

>HMPREF1181_RS00990 efflux RND transporter periplasmic adaptor subunit (Bacteroides stercoris CC31F)
MMKRIIYLLLPLLASCGENSRSSLPTRETVSDVFLQEVLTAKAELKRLQKEFTLAGKVVV
DSDRTISYSPLVSGVVVKSYFSLGDYAEKGKRMVDIRSVELSSLQSELAVARQNLKGVES
LHESGMATDKELVEARSTVGKLQSDFVLYGENQDNGVFSVKAPMSGYVIGKYCNPGTSFP
ESGGPLFSMADLSTVWVVANVYAGNLQFVHEGQCVEITSVAYPAEVFKGKIDFLSQVFDS
EDKALKVRITLPNPALKLKPEMPVVVKLFNDSNLELVAVPSSAVIFDNNGYYVVVGDKTF
GIRKITPFARHNDFTYITEGIKAGEEVVIKNQLLMYNEIKGK