Protein Info for HMPREF1181_RS00360 in Bacteroides stercoris CC31F

Annotation: urocanate hydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 659 PF17391: Urocanase_N" amino acids 79 to 204 (126 residues), 172.5 bits, see alignment E=4.9e-55 TIGR01228: urocanate hydratase" amino acids 89 to 632 (544 residues), 440.7 bits, see alignment E=3.9e-136 PF01175: Urocanase" amino acids 207 to 429 (223 residues), 269 bits, see alignment E=4.4e-84 PF17392: Urocanase_C" amino acids 433 to 631 (199 residues), 275.9 bits, see alignment E=2.5e-86

Best Hits

Swiss-Prot: 49% identical to HUTU_CAEEL: Probable urocanate hydratase (Y51H4A.7) from Caenorhabditis elegans

KEGG orthology group: K01712, urocanate hydratase [EC: 4.2.1.49] (inferred from 91% identity to bhl:Bache_1090)

MetaCyc: 36% identical to HutU (Bacillus subtilis)
Urocanate hydratase. [EC: 4.2.1.49]

Predicted SEED Role

"Urocanate hydratase (EC 4.2.1.49)" in subsystem Histidine Degradation (EC 4.2.1.49)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.49

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (659 amino acids)

>HMPREF1181_RS00360 urocanate hydratase (Bacteroides stercoris CC31F)
MEITLSKTLPPYPTFVEGIRRAPDRGYTLDAAQTATALKNALRYIPTELHETLAPEFMEE
LRTRGRIYGYRYRPQGDLKAKPIDEYKGRCIEGKAFQVMIDNNLCFDIALYPYELVTYGE
TGQVCQNWMQYRLIKQYLEVLTDDQTLVIESGHPLGLFKSKPEAPRVIITNAMMVGLYDN
QQDWHTAMQMGVANYGQMTAGGWMYIGPQGIVHGTFNTLLNAGRLKLGIPQDGDLRGRLF
VSSGLGGMSGAQPKAAEMSGAAAVIAEVDASRIETRHRQGWVGHVTDSLPQAFALAKEAM
DSHTPISIAYHGNVVDLLEYAVKEQIHIDLLSDQTSCHAAYDGGYCPVGLTFEERTRMLH
ENPAEFRRKVDATLKRHFLAIKELVGRGTYFFDYGNSFMKAVYDAGVPEIARNGSDKNGF
IFPSYVEDIMGPELFDYGYGPFRWVCLSGKHEDLVKTDRAAMECIDPTRRGQDLDNYNWI
RDAEKNNLVVGTQARILYQDAEGRMKIALRFNEMVRRGEVGPIMLGRDHHDVSGTDSPFR
ETSNIKDGSNVMADMAVQCFAGNCARGMSLVALHNGGGVGIGKAVNGGFGMVCDGSERVD
EILRSAMLWDVMGGVARRSWARNAHAMETSEEFNRTHAEGYHITMPYVADEELIDKYIK