Protein Info for HMPREF1181_RS00050 in Bacteroides stercoris CC31F

Annotation: threonine synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF14821: Thr_synth_N
  • amino acids 2 to 78 (77 residues), 67.5 bits, E=9.3e-23
• TIGR00260: threonine synthase
  • amino acids 66 to 401 (336 residues), 304.2 bits, E=6.1e-95
• PF00291: PALP
  • amino acids 96 to 378 (283 residues), 94 bits, E=1.1e-30

Best Hits

KEGG orthology group: K01733, threonine synthase [EC: 4.2.3.1] (inferred from 93% identity to bhl:Bache_1166)

Predicted SEED Role

"Threonine synthase (EC 4.2.3.1)" in subsystem Threonine and Homoserine Biosynthesis (EC 4.2.3.1)

MetaCyc Pathways

• superpathway of L-isoleucine biosynthesis I (11/13 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (12/15 steps found)
• aspartate superpathway (19/25 steps found)
• superpathway of L-threonine biosynthesis (5/6 steps found)
• L-threonine biosynthesis (1/2 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (12/18 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism
• Vitamin B6 metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.3.1

Protein Sequence (433 amino acids)

>HMPREF1181_RS00050 threonine synthase (Bacteroides stercoris CC31F)
MQYYSTNKQAPDVTLEEAVVKGLAADKGLFMPFTIKPLPQEFYDSIDTLGFQEIAYRVAD
AFFGEDVPADTLKQIVYDTLSFDVPLVKVTENIYSLELFHGPTLAFKDVGGRFMARLLGY
FIRKEGKKQVNVLVATSGDTGSAVANGFLGVEGIHVYVLYPKGKVSEIQEKQFTTLGQNI
TALEVDGTFDDCQALVKAAFMDKELNSRLQLTSANSINVARFLPQAFYYFYAYAQLKRAG
KAANAVICVPSGNFGNITAGLFGKRMGLPIKRFIASNNRNDIFYQYLQTGVYTPRPSVAT
IANAMDVGDPSNFARVLDLYGGSHAAISAEISGAAYTDEQIAETVKNVWTDEHYLLDPHG
ACGFRALQEGLQPGETGVFLETAHPAKFKDTVENIIGEAVQIPEKLQAFMRGEKKSLPMS
KDFADFKRYLMNI