Protein Info for HGI48_RS21160 in Dickeya dianthicola 67-19

Annotation: kdo(2)-lipid A phosphoethanolamine 7''-transferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 560 transmembrane" amino acids 12 to 30 (19 residues), see Phobius details amino acids 48 to 68 (21 residues), see Phobius details amino acids 79 to 108 (30 residues), see Phobius details amino acids 121 to 141 (21 residues), see Phobius details amino acids 161 to 179 (19 residues), see Phobius details PF08019: EptA_B_N" amino acids 60 to 172 (113 residues), 62.3 bits, see alignment E=5.3e-21 PF00884: Sulfatase" amino acids 251 to 540 (290 residues), 178.7 bits, see alignment E=1.8e-56

Best Hits

Swiss-Prot: 62% identical to EPTB_ECOLI: Kdo(2)-lipid A phosphoethanolamine 7''-transferase (eptB) from Escherichia coli (strain K12)

KEGG orthology group: K12975, phosphoethanolamine transferase (inferred from 94% identity to ddd:Dda3937_01131)

MetaCyc: 62% identical to phosphoethanolamine transferase EptB (Escherichia coli K-12 substr. MG1655)
RXN-16286 [EC: 2.7.8.42]; 2.7.8.42 [EC: 2.7.8.42]; 2.7.8.42 [EC: 2.7.8.42]

Predicted SEED Role

"Phosphoethanolamine transferase specific for the outer Kdo residue of lipopolysaccharide" in subsystem Lipid A modifications

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.8.42

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A7L9RIR1 at UniProt or InterPro

Protein Sequence (560 amino acids)

>HGI48_RS21160 kdo(2)-lipid A phosphoethanolamine 7''-transferase (Dickeya dianthicola 67-19)
MKSLLALSQSTLSWLLAVYIGFFLNLPVFYRRVDAFPFFTENPVAKYIPLLVESMACILF
TFFLMRLLSLGGRRFFRVVASLLVLISVAAGYYMTFFNVVIGYGIIAAVMTTDIDLSKEV
VGLFFVLWVVVLGIPPLFVIWKNRLQQTLIEQLRTQGRRRIALLGLVASAVLVWLPLRYL
DQMNTSAEKLSNQDLPSYGGVVAHSYLPANWLSGFGLFAYARYDENQDDGELIDPSEQFS
YQAPPGIDDTYVVFIIGETTRWDHLGLLGYERDTTPQLAKEPNLLAFRGQSCDTSTKLSM
RCMFVREGGTADNPQRTLREQNIFAVMKSLGFSSELFAMQSEVWFYNNIKADNYAFREMI
ASEKRNEGKAVDDMLLVDEMSQSLMRYPNGKHLVVLHTKGSHYLYSMRYPRRYARYQPEC
MGVDASCSREQLINAFDNSVLYTDAVIKRVIDQLRDKKALLVYSSDHGESIDDNYHLHGT
PRQMAPPEQFRSPVMLWASDKYLAQPRNQQAFEQLRVRQQQGKVLRHEEIFDSMLGCLGY
TSPDGGIQEKNNWCNAPGRE