Protein Info for HGI48_RS18295 in Dickeya dianthicola 67-19

Annotation: Na+/H+ antiporter NhaA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 391 transmembrane" amino acids 12 to 34 (23 residues), see Phobius details amino acids 60 to 77 (18 residues), see Phobius details amino acids 95 to 115 (21 residues), see Phobius details amino acids 127 to 146 (20 residues), see Phobius details amino acids 155 to 175 (21 residues), see Phobius details amino acids 181 to 198 (18 residues), see Phobius details amino acids 210 to 238 (29 residues), see Phobius details amino acids 258 to 278 (21 residues), see Phobius details amino acids 290 to 314 (25 residues), see Phobius details amino acids 330 to 353 (24 residues), see Phobius details amino acids 361 to 382 (22 residues), see Phobius details TIGR00773: Na+/H+ antiporter NhaA" amino acids 11 to 382 (372 residues), 497.4 bits, see alignment E=1.3e-153 PF06965: Na_H_antiport_1" amino acids 11 to 382 (372 residues), 464.7 bits, see alignment E=1.1e-143

Best Hits

Swiss-Prot: 71% identical to NHAA_PECCP: Na(+)/H(+) antiporter NhaA (nhaA) from Pectobacterium carotovorum subsp. carotovorum (strain PC1)

KEGG orthology group: K03313, Na+:H+ antiporter, NhaA family (inferred from 97% identity to ddd:Dda3937_00383)

MetaCyc: 61% identical to Na+:H+ antiporter NhaA (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-129; TRANS-RXN-292

Predicted SEED Role

"Na+/H+ antiporter NhaA type" in subsystem Na(+) H(+) antiporter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A7L9RHJ6 at UniProt or InterPro

Protein Sequence (391 amino acids)

>HGI48_RS18295 Na+/H+ antiporter NhaA (Dickeya dianthicola 67-19)
MIKLFRYLTGLEAAAGMILIAATLLALLVANIPATLPWYQSFLEIPVVMGIGALEINKPL
LLWINDGLMALFFLQVGLEVKRELVVGALASRRQAILPVVAAFGGMLVPALFFLLFNGSE
AETRSGWAIPTATDIAFAVGILVLLGKRVPAGLKVFLLALAIIDDLGAIVIIALFYTQQL
HWVALSGALATIAVLAYMNHQQVMKTSAYLLVGIVLWVCILKSGVHATLAGVIVGFFIPL
RAPAGSPSPAITLEHGLASWIALLVIPLFAFANAGITLQGVAVGHLLSPLTLGIASGLLL
GKPIGVSLFSWLVIRLGLGSLPGGVDFRQVMAVSVLCGIGFTMSIFITLLAFGEVSAQDI
LYAKLAILLTSITTAVLGYLTLRSVLPGAQR