Protein Info for HGI48_RS18105 in Dickeya dianthicola 67-19

Annotation: thiamine/thiamine pyrophosphate ABC transporter permease ThiP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 536 transmembrane" amino acids 12 to 36 (25 residues), see Phobius details amino acids 58 to 80 (23 residues), see Phobius details amino acids 91 to 115 (25 residues), see Phobius details amino acids 136 to 155 (20 residues), see Phobius details amino acids 196 to 218 (23 residues), see Phobius details amino acids 243 to 261 (19 residues), see Phobius details amino acids 286 to 310 (25 residues), see Phobius details amino acids 331 to 354 (24 residues), see Phobius details amino acids 375 to 394 (20 residues), see Phobius details amino acids 402 to 421 (20 residues), see Phobius details amino acids 463 to 484 (22 residues), see Phobius details amino acids 505 to 526 (22 residues), see Phobius details TIGR01253: thiamine/thiamine pyrophosphate ABC transporter, permease protein" amino acids 8 to 525 (518 residues), 800.9 bits, see alignment E=3.3e-245 PF00528: BPD_transp_1" amino acids 75 to 266 (192 residues), 31.4 bits, see alignment E=7.6e-12

Best Hits

Swiss-Prot: 75% identical to THIP_ECOLI: Thiamine transport system permease protein ThiP (thiP) from Escherichia coli (strain K12)

KEGG orthology group: K02063, thiamine transport system permease protein (inferred from 96% identity to ddd:Dda3937_01358)

MetaCyc: 75% identical to thiamine ABC transporter membrane subunit (Escherichia coli K-12 substr. MG1655)
ABC-32-RXN [EC: 7.6.2.15]

Predicted SEED Role

"Thiamin ABC transporter, transmembrane component" in subsystem Thiamin biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.6.2.15

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A7L9RH83 at UniProt or InterPro

Protein Sequence (536 amino acids)

>HGI48_RS18105 thiamine/thiamine pyrophosphate ABC transporter permease ThiP (Dickeya dianthicola 67-19)
MATRRQPLIPGWLWPGLLAAVLLTGTAVLAFAALWLDAPGAPWRSLWDDSYLWHVIRFSF
WQALLSALLSTLPALFLARALYRRRFPGHRLLLRLCAMTLVLPVLVAVFGILSVYGREGW
LARLLMPFGIEYRFSPYGLQGILLAHVFFNLPLATRLFLQALEGIATEQRQLAAQLGLRG
WHFFRLVEWPWLRRQLLPAGALIFMLCFASFATVLALGGGPQATTIELAIYQALSFDYDP
PRAALLALLQMVCCLGLVWFSQRLGRLLAVGAGSRLRWRDPQDSWFSRIADTLLIAAALL
LLLPPLLAVVADGLNRSLPEVLRQPALWQALWTSLRIALAAGALSVVLTLMLLWSSRELK
LRQRQLPAQLLDMSGMLILAMPGIVLASGFFLLFNRTIGLPASPYGLVVLTNALLAIPYA
MKVLENPMYDTAARYSLLCQSLDIRGWHRLRVVELNALRAPIAQALAFASVLSVGDFGII
ALFGNEQFRTLPFYLYQQIGAYRSADGAVTALLLLLLCFTLFTLIEKLAGHDDRAR