Protein Info for HGI48_RS17485 in Dickeya dianthicola 67-19

Annotation: diaminopimelate decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01048: diaminopimelate decarboxylase
  • amino acids 11 to 418 (408 residues), 419.4 bits, E=6.1e-130
• PF02784: Orn_Arg_deC_N
  • amino acids 48 to 275 (228 residues), 187.6 bits, E=2.6e-59
• PF00278: Orn_DAP_Arg_deC
  • amino acids 206 to 376 (171 residues), 81.7 bits, E=3.9e-27

Best Hits

Swiss-Prot: 74% identical to DCDA_ECOLW: Diaminopimelate decarboxylase (lysA) from Escherichia coli (strain ATCC 9637 / CCM 2024 / DSM 1116 / NCIMB 8666 / NRRL B-766 / W)

KEGG orthology group: K01586, diaminopimelate decarboxylase [EC: 4.1.1.20] (inferred from 96% identity to ddd:Dda3937_02577)

MetaCyc: 74% identical to diaminopimelate decarboxylase (Escherichia coli K-12 substr. MG1655)
Diaminopimelate decarboxylase. [EC: 4.1.1.20]

Predicted SEED Role

"Diaminopimelate decarboxylase (EC 4.1.1.20)" in subsystem Lysine Biosynthesis DAP Pathway (EC 4.1.1.20)

MetaCyc Pathways

• aspartate superpathway (24/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (18/18 steps found)
• L-lysine biosynthesis I (9/9 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
• L-lysine biosynthesis III (6/7 steps found)
• L-lysine biosynthesis VI (6/7 steps found)
• L-lysine biosynthesis II (7/9 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Lysine biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.20

Use Curated BLAST to search for 4.1.1.20

Sequence Analysis Tools

See A0A7L9RH59 at UniProt or InterPro

Protein Sequence (423 amino acids)

>HGI48_RS17485 diaminopimelate decarboxylase (Dickeya dianthicola 67-19)
MPHDLNDLSHALNAQSLRALPERFGSPLWAYDAETIIERIGQLRQFDTIRFAQKACSNLH
ILTLMRRQGVKVDSVSLGEIERALAAGFEPGTDAHEIVFTADVLDDATLQRVHELNIPVN
AGSIDMLHQLGERSPGHPVWLRINPGFGHGHSQKTNTGGENSKHGIWYADLPQALEALGR
YRLKLVGIHMHIGSGVDYGHLEQVCDAMVQQVLAVGQDLDAISAGGGLSIPYRHGGEHID
TQHYYGLWNRAREQIAAHLEHPVALEIEPGRFLVAESGVLVAQVRAVKDMGSRHFVLVDA
GFSDLMRPAMYGSYHHITLLPGDGRDLSQCARRDSVVAGPLCESGDVFTQQAGGGVETLA
LPPAQVGDYLVFHDTGAYGASMSSNYNSRPLIAEVLFEQGQPRLIRRRQTLDELLALERG
LVE