Protein Info for HGI48_RS15825 in Dickeya dianthicola 67-19

Annotation: signal peptidase I

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 322 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details transmembrane" amino acids 62 to 82 (21 residues), see Phobius details PF10502: Peptidase_S26" amino acids 60 to 300 (241 residues), 181.4 bits, see alignment E=7.1e-58 TIGR02227: signal peptidase I" amino acids 65 to 159 (95 residues), 87.7 bits, see alignment E=3.8e-29 amino acids 256 to 302 (47 residues), 61.3 bits, see alignment 5.1e-21

Best Hits

Swiss-Prot: 74% identical to LEP_SALTI: Signal peptidase I (lepB) from Salmonella typhi

KEGG orthology group: K03100, signal peptidase I [EC: 3.4.21.89] (inferred from 98% identity to ddd:Dda3937_03849)

MetaCyc: 73% identical to signal peptidase I (Escherichia coli K-12 substr. MG1655)
Signal peptidase I. [EC: 3.4.21.89]

Predicted SEED Role

"Signal peptidase I (EC 3.4.21.89)" in subsystem Signal peptidase (EC 3.4.21.89)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.89

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4CIC4 at UniProt or InterPro

Protein Sequence (322 amino acids)

>HGI48_RS15825 signal peptidase I (Dickeya dianthicola 67-19)
MANMFALILALATLVTGIVWCLERFKWAPARRAKVSALSQQANGAVDEKTLAHNIRQPGW
IETFASVFPVLALVFVVRSFIFEPFQIPSGSMMPTLLIGDFILVEKFAYGIKDPITQTTL
IETGHPKRGDIAVFKYPENPRLDYIKRVVGLPGDRVSYDPIAKQVTIQPGCGDKPSCGSA
LPVTYSNVEPSDFVQTFSGTGREMTSGFYQIPVGQKSEGIRMAVRKETLGEVTHNILTVP
GAQDQLGLYYQQIRQSLGSWVVPTGHYFMMGDNRDNSADSRYWGFVPERNLVGKATAIWM
SFEKQEGEWPTGVRLSRIGGIH