Protein Info for HGI48_RS15705 in Dickeya dianthicola 67-19

Annotation: NO-inducible flavohemoprotein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 409 PF11563: Protoglobin" amino acids 5 to 122 (118 residues), 32.1 bits, see alignment E=2.3e-11 PF00042: Globin" amino acids 41 to 144 (104 residues), 62.5 bits, see alignment E=1.1e-20 PF00970: FAD_binding_6" amino acids 170 to 267 (98 residues), 31.6 bits, see alignment E=3.4e-11 PF00175: NAD_binding_1" amino acids 278 to 385 (108 residues), 52.8 bits, see alignment E=1.2e-17

Best Hits

Swiss-Prot: 96% identical to HMP_DICD3: Flavohemoprotein (hmp) from Dickeya dadantii (strain 3937)

KEGG orthology group: K05916, nitric oxide dioxygenase [EC: 1.14.12.17] (inferred from 96% identity to ddd:Dda3937_03368)

MetaCyc: 66% identical to nitric oxide dioxygenase (Escherichia coli K-12 substr. MG1655)
6,7-dihydropteridine reductase. [EC: 1.5.1.34]; Nitric oxide dioxygenase. [EC: 1.5.1.34, 1.14.12.17]

Predicted SEED Role

"Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (Nitric oxide dioxygenase) (EC 1.14.12.17)" in subsystem Bacterial hemoglobins or Flavohaemoglobin or Glutaredoxins (EC 1.14.12.17)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.14.12.17 or 1.5.1.34

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A7L9RG08 at UniProt or InterPro

Protein Sequence (409 amino acids)

>HGI48_RS15705 NO-inducible flavohemoprotein (Dickeya dianthicola 67-19)
MHLKYNLKTTMRFTMLDQQTIATIKSTIPLLAETGPALTAHFYQRMFHHNPELKDIFNMS
NQRNGDQREALFNAICAYATHIENLPALLPAVERIAQKHASFNIQPEQYQIVGTHLLATL
EEMFQPGQAVLDAWGKAYGVLADVFIQRESDIYQQSAGQNGGWHGTRPFRIVAKQPQSHL
ITSFTLEPADGGPVAAFRPGQYLAVYIRDKRFDYQEIRQYSLTNEPNGRAYRIAVKRETM
GSVSGYLHDVAREGDVIELAAPHGDFYLEVAPETPVALISAGVGQTPMLSMLHSLKNQQH
QADIFWLHAAENTEVHAFADEVADVAAALPSLQSYVWYREAPSEAARSAHVFHGLMALKD
LPEPLPVTALHCYLCGPVAFMQFAARQLLALGITESQIHYECFGPHKVI