Protein Info for HGI48_RS13225 in Dickeya dianthicola 67-19

Annotation: ribonuclease E

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1049 transmembrane" amino acids 114 to 129 (16 residues), see Phobius details TIGR00757: ribonuclease, Rne/Rng family" amino acids 13 to 425 (413 residues), 561.3 bits, see alignment E=6.5e-173 PF00575: S1" amino acids 36 to 117 (82 residues), 48 bits, see alignment 2.6e-16 PF10150: RNase_E_G" amino acids 121 to 391 (271 residues), 326 bits, see alignment E=4.1e-101 PF20833: RNase_E_G_Thio" amino acids 403 to 488 (86 residues), 104.9 bits, see alignment E=3.9e-34 PF12111: PNPase_C" amino acids 1012 to 1047 (36 residues), 61.6 bits, see alignment (E = 7.3e-21)

Best Hits

KEGG orthology group: K08300, ribonuclease E [EC: 3.1.26.12] (inferred from 89% identity to ddd:Dda3937_00056)

Predicted SEED Role

"Ribonuclease E (EC 3.1.26.12)" in subsystem RNA processing and degradation, bacterial or Ribosome biogenesis bacterial (EC 3.1.26.12)

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.26.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A7L9REU1 at UniProt or InterPro

Protein Sequence (1049 amino acids)

>HGI48_RS13225 ribonuclease E (Dickeya dianthicola 67-19)
MKRMLINATQQEELRVALVDGQQLYDLDIESPGHEQKKANIYKGKITRIEPSLEAAFVDY
GAERHGFLPLKEIAREYFPSSYNAHGRPNIKDVLREGQEVIVQVDKEERGNKGAALTTFI
SLAGSYLVLMPNNPRAGGISRRIEGDDRTELKEALGSLELPDGMGLIVRTAGVGKSADAL
QWDLAFRLKHWEAIKKAAEGRSAPFLIHQESNVIVRAFRDYLRPDIGEILIDNPKILELA
KEHIAALGRPDFGSKIKLYTGEIPLFSHYQIESQIESAFQREVRLPSGGSIVIDTTEALT
AIDINSARATRGGDIEETAFNTNLEAADEIARQLRLRDLGGLIVIDFIDMTPVRHQREVE
NRLRDAVRQDRARIQIGRISRFGLLEMSRQRLSPSLGESSHHVCPRCSGTGTIRDNESLS
LSILRLIEEEALKENTKEVHAIVPVPIASYLLNEKREAVNAIEKRQGDVRAIIVPHDGME
TPHYSVLRVRKGEEKQTLSYMLPQLLDVESQPSLEEQTPERRVPEQPALASFTMSDIPPA
ETKPAPVVTAPKAEKQPSSSERGLFGRFVGALKGIFAAPADVKEKPAETVEATSDEQEQK
QERRNNRRQSGRRERPRDNREPRERDEQRRNKRTQPQNADVETAPVAEAPAQDKAVRDEQ
RREQRAERQRRRQEEKRQAQDDVKELNAVTEAADTEDAVAEQEKPAQVMQRRQRRQLTQK
VRVQDSDATGENTEAQLPAAPYVQQSVVEVPEPAALAAEVTNTENDAVESNRENGLPRRS
RRSPRHLRVSGQRRRRYRDERYPAQSPMPMTQASASPEMASGKVWIRYPVAQQQQPERVE
EPVSEFIDAPLSAAPELTAVAVATLPEAVDVLDTAPVSAPATPLSTPTQQETVPTEVPQH
LDANVQEEIAQPQETQQLAPQFAETTALVEEAPAEVVVADSDATTRSEPAETQPTEQPQV
VHEPVLVENTPATQEPVAAVSAPAEISAVVPSQHYAAAPMTRAPAPAYVPDAPRVSDWQR
PAFAFSGKGSAGGHAAEDQASAPATRPVE