Protein Info for HGI48_RS12305 in Dickeya dianthicola 67-19

Annotation: sodium-potassium/proton antiporter ChaA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 366 transmembrane" amino acids 12 to 30 (19 residues), see Phobius details amino acids 37 to 59 (23 residues), see Phobius details amino acids 72 to 94 (23 residues), see Phobius details amino acids 107 to 127 (21 residues), see Phobius details amino acids 143 to 161 (19 residues), see Phobius details amino acids 167 to 188 (22 residues), see Phobius details amino acids 221 to 238 (18 residues), see Phobius details amino acids 258 to 280 (23 residues), see Phobius details amino acids 290 to 312 (23 residues), see Phobius details amino acids 320 to 340 (21 residues), see Phobius details amino acids 347 to 365 (19 residues), see Phobius details TIGR00846: calcium/proton exchanger" amino acids 4 to 364 (361 residues), 357.1 bits, see alignment E=4.6e-111 PF01699: Na_Ca_ex" amino acids 40 to 190 (151 residues), 59 bits, see alignment E=2.8e-20 amino acids 223 to 364 (142 residues), 42.6 bits, see alignment E=3.2e-15

Best Hits

Swiss-Prot: 79% identical to CHAA_ECOLI: Sodium-potassium/proton antiporter ChaA (chaA) from Escherichia coli (strain K12)

KEGG orthology group: K07300, Ca2+:H+ antiporter (inferred from 96% identity to ddd:Dda3937_00118)

MetaCyc: 79% identical to Na+/K+:H+ antiporter ChaA (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-101; TRANS-RXN-42

Predicted SEED Role

"Calcium/proton antiporter"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4D604 at UniProt or InterPro

Protein Sequence (366 amino acids)

>HGI48_RS12305 sodium-potassium/proton antiporter ChaA (Dickeya dianthicola 67-19)
MPTSSDAVKTRHHEYTLIFPLLALLTLTLWGDARSLPATIGINLLALVGILASAFSVVRH
ADVLAHRLGEPYGSLILSLSVVVLEVSLISALMATGDAGPTLMRDTLYSIIMIVSGGLVG
FALLLGGRKFATQYVNLGGIKQYLMAIFPLAVLVLVFPAALPEGNFSVAQSIIIALISAM
MYGVFLLIQTRTHQSLFVYEHEDESDDDNPHHGKPSAHSSAWHTVWLLVHLVAVIGVTKM
DSPQLEGLLEAMNAPAQFTGFLVALLILSPEGLGAINAVLRNQVQRAMNLFFGSVLATIS
LTVPAVTLIATFTGRTLDFALDLPHIVVMLSVLVLCQISFSTGRTNVLNGSAHLALFAAY
LMTIML