Protein Info for HGI48_RS07890 in Dickeya dianthicola 67-19
Annotation: iron-containing alcohol dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 44% identical to YUGK_BACSU: Probable NADH-dependent butanol dehydrogenase 2 (yugK) from Bacillus subtilis (strain 168)
KEGG orthology group: None (inferred from 92% identity to dze:Dd1591_2599)MetaCyc: 37% identical to BdhB (Clostridium acetobutylicum)
1.1.1.-
Predicted SEED Role
"NADH-dependent butanol dehydrogenase A (EC 1.1.1.-)" in subsystem Butanol Biosynthesis (EC 1.1.1.-)
MetaCyc Pathways
- pyruvate fermentation to butanol II (engineered) (5/6 steps found)
- 1-butanol autotrophic biosynthesis (engineered) (20/27 steps found)
- glycerol degradation to butanol (12/16 steps found)
- pyruvate fermentation to butanol I (5/8 steps found)
- superpathway of Clostridium acetobutylicum solventogenic fermentation (7/13 steps found)
- butanol and isobutanol biosynthesis (engineered) (3/8 steps found)
- superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (9/17 steps found)
KEGG Metabolic Maps
- Alkaloid biosynthesis I
- Aminosugars metabolism
- Ascorbate and aldarate metabolism
- Benzoate degradation via CoA ligation
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of type II polyketide products
- Biosynthesis of unsaturated fatty acids
- Bisphenol A degradation
- Butanoate metabolism
- C21-Steroid hormone metabolism
- Fructose and mannose metabolism
- Glycine, serine and threonine metabolism
- Insect hormone biosynthesis
- Linoleic acid metabolism
- Nucleotide sugars metabolism
- Polyketide sugar unit biosynthesis
- Retinol metabolism
- Tetrachloroethene degradation
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.-
Use Curated BLAST to search for 1.1.1.-
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A7L9RC55 at UniProt or InterPro
Protein Sequence (382 amino acids)
>HGI48_RS07890 iron-containing alcohol dehydrogenase (Dickeya dianthicola 67-19) MENFTFFNPTKIEFGVGKEQQIGQHLADHGIKKVLLCYGSERIKRDGLFDIVSQSLREQG IALVECGGIVSNPVISTVREGIALAKAHQVDAILSVGGGSVLDSVKAIAAGVRYDGDIWD LFTGKAPVESALPLFAILTLAATGSEMNPGAVVTNDQTQEKFFISSAALFPKVSIVNPVL MQGVPRDYLVYSASDVIAHLIEVYFTATVHPHLQSRLVESLINTVIETTEALLADPADYG ARAQFAWAATLALNGLTFSGTAGFSYPNHAIEHSLSALFNVPHGAGLSVVVPAWMKWYID RNPAQFERFARNVFGVDSGEQGIAALENWFNAIGTPTRLPQLKITAADLPTIVDNVQGNV RLFGIADTYSPEVVTAILKHAL