Protein Info for HGI48_RS06935 in Dickeya dianthicola 67-19
Annotation: 2-dehydro-3-deoxy-6-phosphogalactonate aldolase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 75% identical to DGOA_ECOLI: 2-dehydro-3-deoxy-6-phosphogalactonate aldolase (dgoA) from Escherichia coli (strain K12)
KEGG orthology group: K01631, 2-dehydro-3-deoxyphosphogalactonate aldolase [EC: 4.1.2.21] (inferred from 95% identity to eca:ECA4417)MetaCyc: 75% identical to 2-dehydro-3-deoxy-6-phosphogalactonate aldolase (Escherichia coli K-12 substr. MG1655)
2-dehydro-3-deoxy-6-phosphogalactonate aldolase. [EC: 4.1.2.21, 4.1.2.55]
Predicted SEED Role
"2-dehydro-3-deoxyphosphogalactonate aldolase (EC 4.1.2.21)" in subsystem D-galactonate catabolism (EC 4.1.2.21)
MetaCyc Pathways
- superpathway of glycolysis and the Entner-Doudoroff pathway (16/17 steps found)
- superpathway of hexuronide and hexuronate degradation (9/10 steps found)
- Entner-Doudoroff pathway I (8/9 steps found)
- 4-deoxy-L-threo-hex-4-enopyranuronate degradation (5/5 steps found)
- D-galacturonate degradation I (5/5 steps found)
- D-fructuronate degradation (4/4 steps found)
- superpathway of β-D-glucuronosides degradation (6/7 steps found)
- D-galactonate degradation (3/3 steps found)
- Entner-Doudoroff shunt (1/2 steps found)
- Entner-Doudoroff pathway III (semi-phosphorylative) (6/9 steps found)
- 3,6-anhydro-α-L-galactopyranose degradation (4/7 steps found)
- D-glucosaminate degradation (1/3 steps found)
- L-glucose degradation (3/7 steps found)
- superpathway of microbial D-galacturonate and D-glucuronate degradation (19/31 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 4.1.2.21 or 4.1.2.55
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A7L9RBN6 at UniProt or InterPro
Protein Sequence (205 amino acids)
>HGI48_RS06935 2-dehydro-3-deoxy-6-phosphogalactonate aldolase (Dickeya dianthicola 67-19) MSWNTNLPLMAILRGITPDEVLEHVAALLDAGFDAVEIPLNSPNPYDSIRLAVEHFGSRA LIGAGTVLKADNVDKLQEIGSKLVVTPNTSPEVIRRAVGYGMTVCPGCATATEAFTALDA GAQSLKIFPSSAFGPDYIKALKAVLPKDVPVFAVGGVTPENLKDYLDAGCVGAGLGSDLY RAGQSVDVTAQKAHAFVNAYKDAVQ