Protein Info for HGI48_RS05890 in Dickeya dianthicola 67-19

Annotation: copper-exporting P-type ATPase CopA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 944 transmembrane" amino acids 287 to 305 (19 residues), see Phobius details amino acids 317 to 338 (22 residues), see Phobius details amino acids 350 to 372 (23 residues), see Phobius details amino acids 384 to 402 (19 residues), see Phobius details amino acids 536 to 558 (23 residues), see Phobius details amino acids 564 to 586 (23 residues), see Phobius details amino acids 882 to 901 (20 residues), see Phobius details amino acids 907 to 926 (20 residues), see Phobius details PF00403: HMA" amino acids 8 to 62 (55 residues), 45 bits, see alignment 2.4e-15 amino acids 73 to 128 (56 residues), 38.6 bits, see alignment 2.3e-13 amino acids 205 to 259 (55 residues), 55.7 bits, see alignment 1.1e-18 TIGR01511: copper-translocating P-type ATPase" amino acids 333 to 931 (599 residues), 601.5 bits, see alignment E=4.6e-184 TIGR01525: heavy metal translocating P-type ATPase" amino acids 352 to 931 (580 residues), 587.1 bits, see alignment E=1.1e-179 TIGR01494: HAD ATPase, P-type, family IC" amino acids 391 to 900 (510 residues), 274.9 bits, see alignment E=2.5e-85 PF00122: E1-E2_ATPase" amino acids 420 to 600 (181 residues), 161.4 bits, see alignment E=3.5e-51 PF00702: Hydrolase" amino acids 618 to 836 (219 residues), 127.8 bits, see alignment E=1.4e-40 PF08282: Hydrolase_3" amino acids 809 to 868 (60 residues), 30 bits, see alignment 8.9e-11

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 93% identity to ddd:Dda3937_04159)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A7L9RBF8 at UniProt or InterPro

Protein Sequence (944 amino acids)

>HGI48_RS05890 copper-exporting P-type ATPase CopA (Dickeya dianthicola 67-19)
MSQTILLSLQGLSCEHCVGRVKKALEARPDVEQADVSLKYANVTGEADSQSLVATIEAAG
YEASPATTPNVTLLLSGLNCQHCVASTRKALEAVPGVAATDVTLQQAAVYGDAEPRALVQ
AIEQAGFHAALAQENALPKSEPLTPHASSPDRLSAAFDSVPANTVRDDNVAHDNGRVHDN
DSIHDNDSVHNSDNAHDNDSVQLLLSGMSCASCVSRVQQALQRVPGVTQARVNLAERSAL
VSGNTSHQALIDAVQNAGYGAEIILDEAERRARQEQTSRQSIRRFRWQAALGLALGIPLM
VWSMIGDNMMLTDDNRSGWLLVGGLTLAVMIAAGGHFYRNAWRSLLNGSATMDTLVALGT
GAAWLYSITVNLWPTWFPMEARHLYYEASAMIIGLINLGHALEQRARQRSSQALERLLDL
TPPTARLVTPQGDRVIPLADVQTGMTLRLTTGDRIPVDGLLEQGELWIDEAMLTGEPIPQ
QKASGDKVHAGTQVQDGSATLRAGAIGNQTTLARIIHLVRQAQSSKPAIGQLADRISAVF
VPVVVAIALLSGAIWYVVGPVPHVVYTLVIATTVLIIACPCALGLATPMSIISGVGRAAE
LGVLVRDADALQQASRLDVLVFDKTGTLTEGKPRVVAIHTFGDISESQALRWAASLEQGA
SHPLAQAIIQRADGVELGDVTQFRTLPGLGVSGQVDGASLLLGNPTLLAQRQIPLTDGEN
APRDGLEKQSALGMTPVLLVANGQVAALFSVQDTLRQDSISALQRLHRQGYQLVMLTGDN
PTTAQAIAREAGIDQVIAGVLPDGKADAIRHLQSQGKRVAMIGDGINDAPALAQADVGIA
MGGGSDIAVETAAMTLMRHSLHGVADALALSRATLANMKQNLLGAFVYNTLGIPIAAGVL
YPLTGTLLNPVVAGAAMALSSITVVSNANRLLRFTPADAPARRD