Protein Info for HGI48_RS05705 in Dickeya dianthicola 67-19

Annotation: peptidylprolyl isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 626 transmembrane" amino acids 12 to 35 (24 residues), see Phobius details PF13624: SurA_N_3" amino acids 1 to 165 (165 residues), 158.2 bits, see alignment E=4.7e-50 PF13623: SurA_N_2" amino acids 2 to 140 (139 residues), 106.6 bits, see alignment E=3.3e-34 PF09312: SurA_N" amino acids 80 to 165 (86 residues), 33.1 bits, see alignment E=1.7e-11 PF13616: Rotamase_3" amino acids 229 to 357 (129 residues), 61 bits, see alignment E=4.8e-20 PF13145: Rotamase_2" amino acids 249 to 370 (122 residues), 71.9 bits, see alignment E=2.5e-23 amino acids 390 to 486 (97 residues), 29.7 bits, see alignment E=3e-10 PF00639: Rotamase" amino acids 279 to 357 (79 residues), 54.6 bits, see alignment E=5.7e-18

Best Hits

Swiss-Prot: 57% identical to PPID_ECOLI: Peptidyl-prolyl cis-trans isomerase D (ppiD) from Escherichia coli (strain K12)

KEGG orthology group: K03770, peptidyl-prolyl cis-trans isomerase D [EC: 5.2.1.8] (inferred from 96% identity to ddd:Dda3937_03316)

Predicted SEED Role

"Peptidyl-prolyl cis-trans isomerase PpiD (EC 5.2.1.8)" (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A7L9RB36 at UniProt or InterPro

Protein Sequence (626 amino acids)

>HGI48_RS05705 peptidylprolyl isomerase (Dickeya dianthicola 67-19)
MMDNLRAAANNVVLKIILALIIGSFVLTGVGDYLIRGSGDYAAKVNGQEITQAQLEQGVQ
NERSRQQEMLGENFSALAANEGYMQQLRKQVLSQLIDETLVVQYAHTLGLNISDEQVKQA
IFSVPEFQTNNRFDNDKYLAQVRQLGLTSDAYAQFLRKQLLTQQLIRGLGNTGFVLQQEL
DNLVAMAAQDRTIRTATIDLSARARNQAVSDEEVKNFYNQNKSRYLAPEQFKVSYIMLDA
ASIMDKAKVDNTDIAAYYEQRKSEFTQPERKKYSVIQLKTEADARAVLEQLKKGADFAAL
AKEKSTDIVSRRNGGDLGWMDGGSTVDEIKQAGLKQKGQLSDVIKSSVGYLIIRLDDIQA
QRVKALDEVRADLAEKVKREKSLDAFYSQQQKLSEAASNDNESLASAEKVANIKAVQTDW
FTRENVPAALNFQPVTQAIFGGSLVGENGTPGNNSDVISVEGDRAFVLRVTEHKPEATQP
LDQVREQVVQTLKRQKAEQQAKVEAEKILADLYQGKTDSMTAAGLSFSAAKEMSSTGQTD
ALAETVFAMQQPKKDKPSYAVAQDQAGNVVLIALDAVKPHVLSDDQKKQFGTQVEQSSVG
ALFDTLLTSLRSQAKIKYGSAAQEVQ