Protein Info for HGI48_RS03240 in Dickeya dianthicola 67-19

Annotation: translation initiation factor IF-2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 905 PF04760: IF2_N" amino acids 1 to 52 (52 residues), 42.1 bits, see alignment 2.4e-14 amino acids 328 to 378 (51 residues), 59.3 bits, see alignment 1e-19 PF08364: IF2_assoc" amino acids 57 to 95 (39 residues), 63.3 bits, see alignment (E = 7.7e-21) TIGR00487: translation initiation factor IF-2" amino acids 320 to 904 (585 residues), 972.2 bits, see alignment E=1.1e-296 TIGR00231: small GTP-binding protein domain" amino acids 407 to 562 (156 residues), 111.6 bits, see alignment E=3.2e-36 PF00009: GTP_EFTU" amino acids 408 to 564 (157 residues), 129.3 bits, see alignment E=5.5e-41 PF00025: Arf" amino acids 409 to 563 (155 residues), 24 bits, see alignment E=9.9e-09 PF01926: MMR_HSR1" amino acids 409 to 514 (106 residues), 41.1 bits, see alignment E=7.1e-14 PF00071: Ras" amino acids 410 to 565 (156 residues), 24 bits, see alignment E=1.1e-08 PF11987: IF-2" amino acids 680 to 794 (115 residues), 150.7 bits, see alignment E=6.5e-48 PF03144: GTP_EFTU_D2" amino acids 825 to 892 (68 residues), 37.6 bits, see alignment 1e-12

Best Hits

Swiss-Prot: 82% identical to IF2_CITK8: Translation initiation factor IF-2 (infB) from Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

KEGG orthology group: K02519, translation initiation factor IF-2 (inferred from 95% identity to ddd:Dda3937_02341)

Predicted SEED Role

"Translation initiation factor 2" in subsystem NusA-TFII Cluster or Translation initiation factors eukaryotic and archaeal or Universal GTPases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A7L9R9W5 at UniProt or InterPro

Protein Sequence (905 amino acids)

>HGI48_RS03240 translation initiation factor IF-2 (Dickeya dianthicola 67-19)
MTDVTLKSLAAEIQTPVDRLIQQFADAGITKSASDSVTQNEKETLLAHLNRERGGAPGKL
TLQRKTRSTLNIPSTGGKSKSVQIEVRKKRTYVKRDPHDEQQAAAEEEQTQREAEEQAQR
AAEDQAKREAEEKAKREEEEKAKRAVAEEQAKREAAEKAKRDVAEKEKVSNQQNDSMTKP
AQAEKARREAEAAELKRKAEESARRKVEEDARRIAEEARQMAEENAGRWEKEGEKSTEDT
DYHVTTSHHAREAEDENDRQVEGDRRGRGRSSKVTKQKKGNRLSESKADREEARAVTRGG
KGKRKPSTLQQGFNKPVQAVNRDVVIGETISVAELANKMAVKGSQVIKAMMKLGAMATIN
QVIDQETAQLVAEEMGHKVILRRENELEEAVMSDRDTGLSSAESRAPVVTIMGHVDHGKT
SLLDYIRSTKVAAGEAGGITQHIGAYHVETDNGMITFLDTPGHAAFTAMRARGAQATDIV
VLVVAADDGVMPQTIEAVQHAKAAKVPVVVAVNKIDKPEADPDRVKNELSQYGIMPEEWG
GESQFVHVSAKSGEGIDELLEAILLQAEVLELKAIRSGMASGVVIESFLDKGRGPVASVL
VREGTLNKGDIVLCGFEYGRVRAMRDELGREITEAGPSIPVEILGLSGVPAAGDEATVVR
DEKKAREVALYRQGKFREVKLARQQKSKLENMFANMTEGEVSELNIVMKADVQGSVEAIS
DSLQKLSTDEVKVKIVGSGVGGITETDATLAAASNAIILGFNVRADASARRIVEAEGLDL
RYYSVIYDLIDEVKQAMSGMLAPEYKQEIIGLAEVRDVFKSPKFGAIAGCMVTEGVVKRH
SPIRVLRDNVVIFEGELESLRRFKDDVNEVRNGMECGIGVKNYNDVRTGDVIEVFETIEI
KRTID