Protein Info for HGI48_RS02385 in Dickeya dianthicola 67-19

Annotation: phosphoserine phosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 325 PF18429: DUF5609" amino acids 38 to 100 (63 residues), 61.4 bits, see alignment E=1.3e-20 TIGR00338: phosphoserine phosphatase SerB" amino acids 103 to 316 (214 residues), 286.2 bits, see alignment E=1.6e-89 TIGR01488: HAD phosphoserine phosphatase-like hydrolase, family IB" amino acids 113 to 284 (172 residues), 85.8 bits, see alignment E=3.5e-28 PF00702: Hydrolase" amino acids 114 to 285 (172 residues), 76.2 bits, see alignment E=9.2e-25 PF12710: HAD" amino acids 115 to 281 (167 residues), 62.4 bits, see alignment E=1.6e-20 PF08282: Hydrolase_3" amino acids 250 to 313 (64 residues), 40.3 bits, see alignment E=6.3e-14

Best Hits

Swiss-Prot: 70% identical to SERB_ECOLI: Phosphoserine phosphatase (serB) from Escherichia coli (strain K12)

KEGG orthology group: K01079, phosphoserine phosphatase [EC: 3.1.3.3] (inferred from 97% identity to ddd:Dda3937_02676)

MetaCyc: 70% identical to phosphoserine phosphatase (Escherichia coli K-12 substr. MG1655)
Phosphoserine phosphatase. [EC: 3.1.3.3]

Predicted SEED Role

"Phosphoserine phosphatase (EC 3.1.3.3)" in subsystem Glycine and Serine Utilization or Serine Biosynthesis (EC 3.1.3.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.1.3.3

Use Curated BLAST to search for 3.1.3.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A7L9R9F2 at UniProt or InterPro

Protein Sequence (325 amino acids)

>HGI48_RS02385 phosphoserine phosphatase (Dickeya dianthicola 67-19)
MSNRLTYSDLPNEINCWPNLPLSLSDDEVMPLDYRAGNTGWLMYGDVLDKYLLSRIQRRL
DEPLVIVSAWSVDDYQVVRLAGILTPRITKVAHELGLDVTPMYNAPSLRSPGLLVMDMDS
TAIQIECIDEIAKLAGTGEHVAEVTERAMRGELDFSASLRQRVGTLKDADANILRQVRDT
LPLMPGLKNMVKQLQDAGWHLAIASGGFTYFADYLRDELGLVAAVANEMGMRDGKLTGDV
VGPIVDAKYKADTLRQLAEKLAIPLPQTVAIGDGANDLLMIKAAGLGIAYHAKPKVNEQS
AVSIRHADLTGVLCILSGSLRHEKS