Protein Info for HGI48_RS02350 in Dickeya dianthicola 67-19

Annotation: Xaa-Pro aminopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 442 signal peptide" amino acids 1 to 34 (34 residues), see Phobius details PF05195: AMP_N" amino acids 6 to 125 (120 residues), 121 bits, see alignment E=2.4e-39 PF00557: Peptidase_M24" amino acids 182 to 413 (232 residues), 231.9 bits, see alignment E=6.8e-73

Best Hits

Swiss-Prot: 77% identical to AMPP_ECOLI: Xaa-Pro aminopeptidase (pepP) from Escherichia coli (strain K12)

KEGG orthology group: K01262, Xaa-Pro aminopeptidase [EC: 3.4.11.9] (inferred from 97% identity to ddd:Dda3937_02682)

MetaCyc: 77% identical to Xaa-Pro aminopeptidase (Escherichia coli K-12 substr. MG1655)
Xaa-Pro aminopeptidase. [EC: 3.4.11.9]

Predicted SEED Role

"Xaa-Pro aminopeptidase (EC 3.4.11.9)" (EC 3.4.11.9)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.11.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A7L9R9C4 at UniProt or InterPro

Protein Sequence (442 amino acids)

>HGI48_RS02350 Xaa-Pro aminopeptidase (Dickeya dianthicola 67-19)
MNQQEYLRRRLALLDKMAPGSAAILFAAPQAQRNADSDYPYRQSSDFWYFTGFNEPEAAL
LLIKSDENHHHSVLFNRVRDVTAEIWFGRRLGQEAAPAKLGVDRALPFSEIGEQLHLLLN
GLDVVYHAQGEYAYADKLVFAALETLRTGGTRKGFHAPATLTDWRPWVHNMRLFKSPAEI
DTLRRAGEISALAHTRAMEKCRPGMFEYQLEGEIHHEFNRHGARYPSYNTIVGSGENACI
LHYTENESQMRDGDLVLIDAGCEYQGYAGDITRTFPVNGKFTPAQRAIYDIVLESEVRAI
EMFAPGRSIREVNEEVVRIMLRGLIKLGILQGDVDDLFAEQAHRRFFMHGLSHWLGMDVH
DVGDYGTADRGRALEPGMVLTVEPGLYIAPDADVPPKYRGIGIRIEDDIVITENGNDVLT
GDVVKDPDQIEALMARAAGQIS