Protein Info for HGI48_RS01020 in Dickeya dianthicola 67-19

Annotation: UDP-N-acetylmuramate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00179: UDP-N-acetylenolpyruvoylglucosamine reductase
  • amino acids 8 to 332 (325 residues), 362.1 bits, E=1e-112
• PF01565: FAD_binding_4
  • amino acids 24 to 153 (130 residues), 82.8 bits, E=1.9e-27
• PF02873: MurB_C
  • amino acids 209 to 332 (124 residues), 113.1 bits, E=6.2e-37

Best Hits

Swiss-Prot: 67% identical to MURB_SALCH: UDP-N-acetylenolpyruvoylglucosamine reductase (murB) from Salmonella choleraesuis (strain SC-B67)

KEGG orthology group: K00075, UDP-N-acetylmuramate dehydrogenase [EC: 1.1.1.158] (inferred from 90% identity to ddd:Dda3937_04216)

MetaCyc: 65% identical to UDP-N-acetylenolpyruvoylglucosamine reductase (Escherichia coli K-12 substr. MG1655)
UDPNACETYLMURAMATEDEHYDROG-RXN [EC: 1.3.1.98]

Predicted SEED Role

"UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158)" in subsystem Peptidoglycan Biosynthesis or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 1.1.1.158)

MetaCyc Pathways

• peptidoglycan biosynthesis I (meso-diaminopimelate containing) (12/12 steps found)
• peptidoglycan recycling I (13/14 steps found)
• UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing) (8/8 steps found)
• UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing) (7/8 steps found)
• UDP-N-acetylmuramoyl-pentapeptide biosynthesis III (meso-diaminopimelate containing) (6/8 steps found)
• peptidoglycan biosynthesis III (mycobacteria) (11/15 steps found)
• peptidoglycan biosynthesis II (staphylococci) (12/17 steps found)
• peptidoglycan biosynthesis IV (Enterococcus faecium) (12/17 steps found)
• peptidoglycan biosynthesis V (β-lactam resistance) (11/17 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Nucleotide sugars metabolism
• Peptidoglycan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.158 or 1.3.1.98

Sequence Analysis Tools

See A0A7L9R8Q2 at UniProt or InterPro

Protein Sequence (345 amino acids)

>HGI48_RS01020 UDP-N-acetylmuramate dehydrogenase (Dickeya dianthicola 67-19)
MTNSVTSLKSFNSFSLSVFATEAATVKNSSELLSVWQRAAQGGLPILILGEGSNVLFLDD
FHGIVLVNRLKGIEIKETTSEWMLHVGAGENWHYLVEYTQERQIAGLENLALIPGCVGSA
PIQNIGAYGVELKQVCAYVDMLNLRTGEIARLSAEECRFGYRDSVFKHEYQDGFAIIAVG
LRLSKEWKPVLEYGDLTRLDPSAVTAKQVFDAVCQMRRSKLPDPAVMGNAGSFFKNPVIP
AAIAEHILASYPNAPHYPQLNGEVKLAAGWLIDQCGLKGYQIGQAAVHDKQALVLVNKGE
ATSRDLVNLARYVRNRVAEQFEVWLEPEVRFIAAQGEVNALEVLA