Protein Info for HGI48_RS00100 in Dickeya dianthicola 67-19

Annotation: formyl-CoA transferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 425 TIGR03253: formyl-CoA transferase" amino acids 8 to 424 (417 residues), 704.9 bits, see alignment E=1.5e-216 PF02515: CoA_transf_3" amino acids 9 to 402 (394 residues), 293.5 bits, see alignment E=1.3e-91

Best Hits

Swiss-Prot: 68% identical to FCTA_ECO81: Formyl-CoA:oxalate CoA-transferase (frc) from Escherichia coli O81 (strain ED1a)

KEGG orthology group: K07749, formyl-CoA transferase [EC: 2.8.3.16] (inferred from 97% identity to dda:Dd703_2501)

MetaCyc: 68% identical to formyl-CoA transferase (Escherichia coli K-12 substr. MG1655)
Formyl-CoA transferase. [EC: 2.8.3.16]

Predicted SEED Role

"Formyl-coenzyme A transferase (EC 2.8.3.16)" (EC 2.8.3.16)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 2.8.3.16

Use Curated BLAST to search for 2.8.3.16

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A7L9R887 at UniProt or InterPro

Protein Sequence (425 amino acids)

>HGI48_RS00100 formyl-CoA transferase (Dickeya dianthicola 67-19)
MNNNKDLPLAGVKIIDFTHVQAGPACTQMLAWFGADVIKIERPGSGDITRNQLRDIPDAD
ALYFTMLNSNKRSLTLDTKKPEGKEVLTRLIKESDVMVENFGPGALDRMGFTWEHIQELN
PRMILASVKGFSEGHHYEHLRAYENVAQCAGGAASTTGWWKGENAGPTISAAALGDSNTG
MHLAIGILTAYIGRQKTGKGQKVACAMQDAVLNLCRVKMRDQLRLDNVGYLEEYPQYPHE
PFTDVVPRGGNAGGGGQPGWILKCKGWESDPNAYIYFTVQDLVWTPICDAIERPEWREDP
AYTTPKARQPHIMDIFGAIESFILASGKDKYDAVEYFGKFSIPCAPVMSMKELLHDESLR
KSGSIVEVPHKVRGSYWTVGCPIKFSTLKPEITASPLLGEHTDDVLAELGYSTEQIALIH
TAKAV