Protein Info for HER17_RS21400 in Pectobacterium carotovorum WPP14

Annotation: uracil-xanthine permease family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 462 transmembrane" amino acids 39 to 62 (24 residues), see Phobius details amino acids 69 to 89 (21 residues), see Phobius details amino acids 127 to 148 (22 residues), see Phobius details amino acids 157 to 181 (25 residues), see Phobius details amino acids 193 to 211 (19 residues), see Phobius details amino acids 218 to 239 (22 residues), see Phobius details amino acids 259 to 280 (22 residues), see Phobius details amino acids 349 to 371 (23 residues), see Phobius details amino acids 378 to 398 (21 residues), see Phobius details amino acids 407 to 428 (22 residues), see Phobius details amino acids 437 to 457 (21 residues), see Phobius details TIGR00801: uracil-xanthine permease" amino acids 28 to 456 (429 residues), 453 bits, see alignment E=1e-139 PF00860: Xan_ur_permease" amino acids 33 to 425 (393 residues), 363.1 bits, see alignment E=7.4e-113 TIGR03173: xanthine permease" amino acids 39 to 458 (420 residues), 416.3 bits, see alignment E=1.2e-128

Best Hits

Swiss-Prot: 85% identical to XANP_ECOL6: Xanthine permease XanP (xanP) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K03458, nucleobase:cation symporter-2, NCS2 family (inferred from 98% identity to eca:ECA0035)

MetaCyc: 85% identical to xanthine:H+ symporter XanP (Escherichia coli K-12 substr. MG1655)
RXN-5076

Predicted SEED Role

"Xanthine permease" in subsystem Purine Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (462 amino acids)

>HER17_RS21400 uracil-xanthine permease family protein (Pectobacterium carotovorum WPP14)
MTTTTETSQTEAAAAPQRSELIYHLEDRPPLPQTLFAASQHLLAMFVAVITPALLICQAL
GLPAEDTQRIISMSLFASGLASILQIKTWGPVGSGLLSIQGTSFNFVTPLIMGGLALKNG
GADVPTMMAALFGTLMVASFTEIILSRFLHLTRRIITPLVSGIVVMIIGLSLIQVGLTSI
GGGYAAMGNNTFGAPKNLLLAGVVLLVIILLNRQRNPYLRVASLVIAMAVGYLGAWLMGM
LPENTPAQNDTVIMVPTPLHYGLGFDWNLLIPLMLVFMVTSLETIGDITATSDVSEQPVR
GPLYMKRLKGGVLANGLNSCLSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVSLMLIA
LGLFPAVSGFVQHIPEPVLGGATIVMFGTIAASGVRIVSREPLNRRAIMIIALSLAVGLG
VSQQPLILQFAPDWIKTLLSSGIAAGGITAIVLNIVFPHEEK