Protein Info for HER17_RS20975 in Pectobacterium carotovorum WPP14

Annotation: aldehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 14 to 472 (459 residues), 555.9 bits, E=3.2e-171

Best Hits

Swiss-Prot: 74% identical to ALDA_ECOLI: Lactaldehyde dehydrogenase (aldA) from Escherichia coli (strain K12)

KEGG orthology group: K07248, lactaldehyde dehydrogenase / glycolaldehyde dehydrogenase [EC: 1.2.1.21 1.2.1.22] (inferred from 98% identity to pct:PC1_4133)

MetaCyc: 74% identical to aldehyde dehydrogenase A (Escherichia coli K-12 substr. MG1655)
Lactaldehyde dehydrogenase. [EC: 1.2.1.22]; Glycolaldehyde dehydrogenase. [EC: 1.2.1.22, 1.2.1.21]

Predicted SEED Role

"Aldehyde dehydrogenase A (EC 1.2.1.22) / Glycolaldehyde dehydrogenase (EC 1.2.1.21)" in subsystem L-rhamnose utilization or Methylglyoxal Metabolism (EC 1.2.1.21, EC 1.2.1.22)

MetaCyc Pathways

• superpathway of glycol metabolism and degradation (6/7 steps found)
• L-lactaldehyde degradation (aerobic) (2/2 steps found)
• ethylene glycol degradation (2/2 steps found)
• superpathway of fucose and rhamnose degradation (9/12 steps found)
• methylglyoxal degradation IV (2/3 steps found)
• methylglyoxal degradation V (2/3 steps found)
• superpathway of methylglyoxal degradation (5/8 steps found)
• lactate biosynthesis (archaea) (2/5 steps found)
• D-arabinose degradation II (1/4 steps found)
• L-rhamnose degradation II (2/8 steps found)
• superpathway of pentose and pentitol degradation (12/42 steps found)

KEGG Metabolic Maps

• Glyoxylate and dicarboxylate metabolism
• Pyruvate metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.22

Use Curated BLAST to search for 1.2.1.21 or 1.2.1.22

Protein Sequence (479 amino acids)

>HER17_RS20975 aldehyde dehydrogenase (Pectobacterium carotovorum WPP14)
MSTTQKRMYINGEFVENRSGKWIDVVNPATEQVISQIPEGSADDAKRAIEAAEAAQPGWE
ALPAVERGVWLHKIADGIREREAELTDTIIAEGGKTHGLAQTEVLFTADYLDYMAEWARR
YEGEIIQSDRPNENIFVFRKAIGVTTGILPWNFPFFLIARKAAPALITGNTIVIKPSEIT
PNNAVIFAEIIHKIGLPKGVINFVTGYGPTVGQELAANPKVGMVSLTGSVAAGIATMTAA
AQNVTKVSLELGGKAPAIVMDDADLDLAVKAIVSSRVINSGQVCNCAERVYVQKGIYDEF
ISRIKTAMEQVTFGNTAEKKALDMGPLISAAARQRVEDKVAKAVSQGAKVLLGGQRESGT
GYFYPPTLLVDVKQDMPIMHEEVFGPVLPVATFDTLEEAITMANDSEYGLTSSIYTQNIN
TAMKALKGLKFGETYINRENFEAMQGFHAGWRKSGVGGADGKHGLQEYLQTHVAYLQFH