Protein Info for HER17_RS19630 in Pectobacterium carotovorum WPP14

Annotation: CRISPR-associated helicase Cas3'

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 905 PF18019: Cas3_HD" amino acids 15 to 231 (217 residues), 120.8 bits, see alignment E=1.3e-38 TIGR01596: CRISPR-associated endonuclease Cas3-HD" amino acids 33 to 226 (194 residues), 67 bits, see alignment E=2.2e-22 PF00270: DEAD" amino acids 282 to 490 (209 residues), 28.2 bits, see alignment E=2.3e-10 TIGR01587: CRISPR-associated helicase Cas3" amino acids 301 to 672 (372 residues), 230.2 bits, see alignment E=4e-72

Best Hits

KEGG orthology group: K07012, (no description) (inferred from 88% identity to pwa:Pecwa_0397)

Predicted SEED Role

"CRISPR-associated helicase Cas3" in subsystem CRISPRs

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (905 amino acids)

>HER17_RS19630 CRISPR-associated helicase Cas3' (Pectobacterium carotovorum WPP14)
MDKEDIIDRRYFQYWGKAKRAADALEGDDYHLLPYHGLDVAACGYFLLKGNYFQANHVLR
ELVFGDDDVAAWFAYFLAWHDIGKFARGFQSKYANPDSPLVQHSGQSGKDRHDDLGFWLW
TMRDDIPNLFPLGTKKPTSVVKNTLEIWLNIVTGHHGKPAAECKGSLAFHRDDYLAVEHY
LHDLETCFPDASAFPACFADKGWRNRLKQQSWALAGLTVLADWLGSRQQDFRYCSTPMPL
ETYWREHALPTAEKVVSRLPRTPSPVPFHSIQQLFPFIQRPTPLQQQALEADISADGPQL
FILEDVTGAGKTEAAMVLAHRLMAQQKASGIYVGLPTMATANAMYLRLAKAYHALYSPEH
SPSLMLAHGARHMSSAFMQSLWEGDSQGQAQYDKKENAASKDCNIWFADSRKKALLADIG
VGTLDQALMAVMPFRYQSLRVLGLQNKLLILDEVHAYDAYMSKLIELLIGFHAQQGGSVI
ILTATLPLNLREKLTWAFAQGIACEAVQLNPDADYPWMTQLTRECLREARLDTRAEVRGE
VKIGWLTERLQGIERVKAAVAAGQSICWIRNTVDDAIAVYRQLIEAGIAEENMLLFHSRF
AFFDRMAIEAQALTWFGKDSTPEQRAGKVLIATQVVEQSLDIDVDNMISDLAPIDLLIQR
AGRLQRHIRFLDGRRKTEMDTAPLTDERPAAVLHIMAPVWQPEAGADWLGDELRNSGYVY
PDHAALWRTQAILREHGAIKMPEAARQLINSVYEEQIAVPPALEAIANKVLGERYGQRSV
AGQSSLALVHGYCAQSSESGWSDAVDISTRLGEETLDLYLAWKPENDGELPQPYAASDTF
AWEQSRVQVRLSWWQKRKTGLPILEGDALEQFRQQLHRPQAEVLLLNRGETHAFYSERVG
LMLLG