Protein Info for HER17_RS18720 in Pectobacterium carotovorum WPP14

Annotation: MFS transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 433 transmembrane" amino acids 7 to 26 (20 residues), see Phobius details amino acids 47 to 69 (23 residues), see Phobius details amino acids 76 to 95 (20 residues), see Phobius details amino acids 101 to 122 (22 residues), see Phobius details amino acids 135 to 159 (25 residues), see Phobius details amino acids 165 to 185 (21 residues), see Phobius details amino acids 234 to 255 (22 residues), see Phobius details amino acids 267 to 288 (22 residues), see Phobius details amino acids 302 to 322 (21 residues), see Phobius details amino acids 327 to 349 (23 residues), see Phobius details amino acids 361 to 384 (24 residues), see Phobius details amino acids 391 to 412 (22 residues), see Phobius details PF07690: MFS_1" amino acids 16 to 287 (272 residues), 173.9 bits, see alignment E=2.3e-55 amino acids 301 to 420 (120 residues), 35.5 bits, see alignment E=2.8e-13 TIGR00893: D-galactonate transporter" amino acids 17 to 411 (395 residues), 401 bits, see alignment E=2.8e-124

Best Hits

Swiss-Prot: 85% identical to EXUT_ECO57: Hexuronate transporter (exuT) from Escherichia coli O157:H7

KEGG orthology group: K08191, MFS transporter, ACS family, hexuronate transporter (inferred from 97% identity to pwa:Pecwa_0745)

MetaCyc: 85% identical to hexuronate transporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-123; TRANS-RXN-35

Predicted SEED Role

"Hexuronate transporter" in subsystem Alginate metabolism or D-Galacturonate and D-Glucuronate Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (433 amino acids)

>HER17_RS18720 MFS transporter (Pectobacterium carotovorum WPP14)
MRKIKGLRWYMIGLVTIGTVLGYLTRNAISVAAPTLQDQLHITTQQYSYIVAAYSACYTI
MQPIAGYVLDLLGTKIGYAMFAILWAIFCMGTALANSWGGLAIARGAVGMAEAAMIPAGL
KASSEWFPAKERSVAVGYFNVGSSIGAMIAPPLVVWAIVAHSWEMAFIITGALSLIWAIC
WLVFYKHPKDQKKLSDEERDYILSGQEAQHQTNNAKKMSAWQILRNRQFWGIALPRFLAE
PAWGTFNAWIPLFMFKAYGFNLKEIAMFAWMPMLFADIGCILGGYLPMLFQKHFKVNLIV
SRKLVVTMGAVLMIAPGMIGLFSSPYVAIALLCVGGFAHQSLSGALITLSSDVFGRNEVA
TANGLTGMAAWMASTMFALVVGALADTLGFSPLFAALAVFDLLGAVVIWTVLKNQPASEV
AAAAETLKEANQH