Protein Info for HER17_RS17945 in Pectobacterium carotovorum WPP14

Annotation: LacI family DNA-binding transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 334 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF00356: LacI" amino acids 3 to 47 (45 residues), 39.9 bits, see alignment 4.2e-14 PF00532: Peripla_BP_1" amino acids 59 to 316 (258 residues), 154 bits, see alignment E=9.3e-49 PF13377: Peripla_BP_3" amino acids 169 to 330 (162 residues), 71.7 bits, see alignment E=1.3e-23

Best Hits

Swiss-Prot: 53% identical to RAFR_ECOLX: HTH-type transcriptional regulator RafR (rafR) from Escherichia coli

KEGG orthology group: K02529, LacI family transcriptional regulator (inferred from 95% identity to pct:PC1_0634)

Predicted SEED Role

"Putative ThuR, regulatory protein for trehalosemaltose transport"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (334 amino acids)

>HER17_RS17945 LacI family DNA-binding transcriptional regulator (Pectobacterium carotovorum WPP14)
MSLKTIANNLGLSVAAVSRALNGHRDISDATRQRIQEEAERIGYRPNTHARRLKTGKSNA
VGLVYPYASSLSNDIFFEMIGAISRKLAQHEVDFLLLADEQDACQGAARLIASRRIDALI
VAHTCEQDARLTLLQRHNVPFLALGRSQLPHPYAWFDFDNRAGMMLATEHLIALGHRRIA
ILSEDHPQAFIMQRRQGYRDALQRHGLPFHDVYLRCVNPTRRAGYQAMLDLLALPEPPTA
MVMDGNVHGDGAVAALQQAGRLSGSHPIALVMYDGLPQDSLTDITVTAIEQATREQVGEQ
IASMMQALIAGEAVENLQVLWQPTLRLGKTSFPA