Protein Info for HER17_RS16220 in Pectobacterium carotovorum WPP14

Annotation: DNA mismatch repair protein MutS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 854 TIGR01070: DNA mismatch repair protein MutS" amino acids 12 to 852 (841 residues), 1314.6 bits, see alignment E=0 PF01624: MutS_I" amino acids 13 to 124 (112 residues), 147.8 bits, see alignment E=3.5e-47 PF05188: MutS_II" amino acids 133 to 258 (126 residues), 135.3 bits, see alignment E=4.4e-43 PF05192: MutS_III" amino acids 274 to 561 (288 residues), 177 bits, see alignment E=1.5e-55 PF05190: MutS_IV" amino acids 430 to 519 (90 residues), 103.6 bits, see alignment E=1.4e-33 PF00488: MutS_V" amino acids 612 to 799 (188 residues), 304.3 bits, see alignment E=1e-94

Best Hits

Swiss-Prot: 85% identical to MUTS_CROS8: DNA mismatch repair protein MutS (mutS) from Cronobacter sakazakii (strain ATCC BAA-894)

KEGG orthology group: K03555, DNA mismatch repair protein MutS (inferred from 97% identity to eca:ECA1053)

MetaCyc: 83% identical to DNA mismatch repair protein MutS (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"DNA mismatch repair protein MutS" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (854 amino acids)

>HER17_RS16220 DNA mismatch repair protein MutS (Pectobacterium carotovorum WPP14)
MKDSTDKDFTAHTPMMQQYFRLKAEHPEILLFYRMGDFYELFYDDAKRASQLLDISLTKR
GASAGEPIPMAGVPHHAVENYLARLVQMGESVAICEQIGDPATSKGPVERKVVRIVTPGT
ISDEALLQEKQDNLLAAIWQDGRGFGYATLDISSGRFRVSEPADRETMAAELQRTNPAEL
LYPESFESMDLIENRHGLRRRPLWEFEPDTARQQLNLQFGTRDLTGFGVEQAKLALRAAG
CLLQYAKDTQRTSLPHIRGITMERQQDGIIMDAATRRNLELTQNLSGGVENTLAAVLDCT
VTAMGSRMLKRWIHMPSRDIEALKQRQQAISALQDIAPDLQPSLRQVGDLERILARLALR
TARPRDLARMRHAFQQFPDIREQLAPLDTDSVRRLVSLIGQFDELRDLLERAVVEAPPVL
VRDGGVIAPGYHAELDEWRALADGASDYLDRLEIREREKLGLDTLKVGFNGVHGYYIQVS
RGQSHLVPIHYVRRQTLKNAERYIIPELKEYEDKVLTSKGKALALEKALYDELFDLLLPH
LAELQQSAAALAELDVLTNLAERADTLNYVCPTLSDKSGIKITGGRHPVVEQVLREPFIS
NPLSLAPQRRMLIITGPNMGGKSTYMRQAALIVLMAHIGCFVPADQAVIGPVDRIFTRVG
AADDLASGRSTFMVEMTETANILHNATENSLVLMDEIGRGTSTYDGLSLAWACAENLANR
IKAMTLFATHYFELTTLPEKMEGVVNVHLDAREHGDTIAFMHSVQDGAASKSYGLAVAAL
AGVPKEVIKRARQKLKELETLSNNASSSHIDGAQLALLSNDEPSPAIEALEAIDPDALTP
RQALDWLYQLKKML