Protein Info for HER17_RS15580 in Pectobacterium carotovorum WPP14

Annotation: two-component system sensor histidine kinase RcsC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 951 transmembrane" amino acids 16 to 38 (23 residues), see Phobius details amino acids 311 to 336 (26 residues), see Phobius details PF00512: HisKA" amino acids 469 to 533 (65 residues), 66.5 bits, see alignment 3.5e-22 PF02518: HATPase_c" amino acids 580 to 690 (111 residues), 96.8 bits, see alignment E=2.1e-31 PF09456: RcsC" amino acids 708 to 798 (91 residues), 122.1 bits, see alignment E=1.4e-39 PF00072: Response_reg" amino acids 827 to 936 (110 residues), 96.4 bits, see alignment E=2.4e-31

Best Hits

KEGG orthology group: K07677, two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC: 2.7.13.3] (inferred from 96% identity to pct:PC1_1106)

Predicted SEED Role

"Two-component sensor protein RcsC (EC 2.7.3.-)" (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (951 amino acids)

>HER17_RS15580 two-component system sensor histidine kinase RcsC (Pectobacterium carotovorum WPP14)
MKYLASFQTTLKVSRYLFRVLAVMLWVLGALISVFYVTKVLNEKESELRQEYNLSFDQSQ
GYIRHASDIVRELQYLAANRLMLAREKAEPPAEGGPGVSVYALAPGATCSTQYGGNAALL
SLSHFFNGWQDNFSAVYDLNRVFFVGGDRRCMVDFGIRNQSLDRDNLLKNVQDRFQEQKK
SRTQSGRDETVYWITPASIPDVGYLYALTPIYVDSKLEVIMGIEQTIRLDDFVTMGKFPI
SARLLDQYNQVVLQFSDDKERYASSVDGYPSEHNYFGYVNGYDELILKKSLPPTSFGIVY
SLPLKVLLSHISALMINMLMLNMLSAILLFVLALVFERKMLLPAEVNAFQLEENEQFNRK
IVASAPVGICILRINDGTNILSNELAHNYLNLLTHEDRLRITRIICEQQSKFVDVMTSRN
HHLQISFVHSRYRNENVAICVLLDVSARVKMEESLQEMANAAEQASQSKSMFLATVSHEL
RTPLYGIIGNLDLLQTKSLPQDANRLVAAMNNSSSLLLKIISDILDFSKIESEQLKIEAC
EFAPHEVISHITSNYLPLVVKKRLTLYCFIDPNVPVSLFGDPVRLQQVLSNLLSNAIKFT
DTGCIIFEVGCRDGYLEFVVRDTGVGIQPREAVKLFDPFFQAGSGVQRHFQGTGLGLAIC
EKLVNLMDGDITIESEPGLGSLFGVRIPLYKARYAPAAINASLQGKMCWLRIRNARLEAY
LLTLLQEQGVQVARYQNQTVSPDDVMISDYASEEDVNVRAHIVMSGAHNGSAQEVSDGHW
VQGTSTPQHLPDLLEKIYRSESEDRNRVEISPPLTSYIRAENGDIMILVVDDHPINRRLL
ADQLGSLGYQAMTANDGIDALGVLSKNHIDIVLTDVNMPNMDGYLFTRRMREQGLRFPVI
GVTANALAEERERCLGAGMDHCLSKPVTLDTLQQSLAHYSNVVRQARTSEE