Protein Info for HER17_RS15045 in Pectobacterium carotovorum WPP14

Annotation: two-component system sensor histidine kinase KdpD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 920 transmembrane" amino acids 402 to 423 (22 residues), see Phobius details amino acids 430 to 447 (18 residues), see Phobius details amino acids 453 to 472 (20 residues), see Phobius details amino acids 481 to 502 (22 residues), see Phobius details PF02702: KdpD" amino acids 23 to 231 (209 residues), 319.3 bits, see alignment E=2.4e-99 PF13493: DUF4118" amino acids 406 to 512 (107 residues), 100.3 bits, see alignment E=1.3e-32 PF13492: GAF_3" amino acids 534 to 652 (119 residues), 64.1 bits, see alignment E=4.4e-21 PF00512: HisKA" amino acids 672 to 737 (66 residues), 47.1 bits, see alignment 5.1e-16 PF02518: HATPase_c" amino acids 784 to 907 (124 residues), 87.4 bits, see alignment E=2.4e-28

Best Hits

KEGG orthology group: K07646, two-component system, OmpR family, sensor histidine kinase KdpD [EC: 2.7.13.3] (inferred from 95% identity to eca:ECA1339)

Predicted SEED Role

"Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)" in subsystem Potassium homeostasis (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (920 amino acids)

>HER17_RS15045 two-component system sensor histidine kinase KdpD (Pectobacterium carotovorum WPP14)
MIDGEDRRPDPDSLLAQVGAPPRGKLKIFFGACAGVGKTYAMLQEAQRLRAQGLDILVGV
VETHGRSETAALLEGLPLLPLRHFRHHGRHTVEFDLDAALARCPALILIDELAHSNVNGS
RHPKRWQDVQELLDAGIDVFTTVNVQHLESLNDVVGGVTGIRVRETVPDPIFDQASEVIL
VDLPPDDLRQRLNEGKVYLPLQAERAVENFFRKGNLIALRELALRRMADRVDDQMRAMRA
GKGREQVWHTRDAILLCIGHGTGNEKLVRTAARLAARLGSAWHAVYVETPRLHRLPEPQR
RAILRALKLAQDLGAETVTLSEPDEELAVLRYAREHNLGKIVIGRHVEQRFGWWWRTRFA
ERLGRLGPDLDLVVVAVQDDAPAAPIKTPDARGLVEKWRMQLFGCGLATLLCAFITLLAS
WSPFAMLEPVNLVMIYLLAVVIVALFFGRWPSVFAAVINVASFDLFFILPRGTFAVSDAQ
YLVTFAVMLGVGLLVGNLTAGVRYQARVARYREQRVRHLYEMSKALNRSLSSTDIVEASQ
HFLSTTFQARIAVLLADNLHHSSPELAHPARDSQQLIVDHAIARWSFDHRAPAGAGTSTL
PGVSYQILPLATTQQIFGVLAIEPNNARQLMIPEQQRLLETFTVLIANALERLHLVQSTE
NARLDAEREQLRNSLLAALSHDLRTPLTVLFGQAEILTLNLASEGSPYAQQANQIRQHIL
NTTRLVNNLLDMARIQSDGFNLRKEWQTPEELIGSALQQLESALAKNTIQVNLPDEMVLV
YCDAGLVERVFINLLENALKYAGEQATIAISARVIPASLISESTASQPDAQESALEIIVQ
DNGPGIEHGQESMIFDKFSRGHKESSIPGVGLGLAICRAIVEIHGGRIWATNAESGGAAF
HFTLPLSAPPDLDPEDIEEH