Protein Info for HER17_RS14755 in Pectobacterium carotovorum WPP14

Annotation: molybdenum-dependent transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 263 TIGR00637: ModE molybdate transport repressor domain" amino acids 16 to 107 (92 residues), 126 bits, see alignment E=5e-41 TIGR00638: molybdenum-pterin binding domain" amino acids 122 to 189 (68 residues), 84.7 bits, see alignment E=3.4e-28 PF03459: TOBE" amino acids 124 to 186 (63 residues), 56.3 bits, see alignment E=1.6e-19 amino acids 197 to 259 (63 residues), 33.1 bits, see alignment E=2.7e-12

Best Hits

Swiss-Prot: 72% identical to MODE_YERPE: Transcriptional regulator ModE (modE) from Yersinia pestis

KEGG orthology group: K02019, molybdate transport system regulatory protein (inferred from 96% identity to pct:PC1_1267)

Predicted SEED Role

"DNA-binding domain of ModE / Molybdate-binding domain of ModE" in subsystem Molybdenum cofactor biosynthesis or Transport of Molybdenum

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (263 amino acids)

>HER17_RS14755 molybdenum-dependent transcriptional regulator (Pectobacterium carotovorum WPP14)
MQAEILLTLKLQQRLFADPRRIELLKQIRHTGSISQGAKLAGISYKSAWDAINEMNQLAE
QIIVERMTGGKGGGGAQLTRYGERLLQLYDLLAQIQQKAFDVLQEDGLPLDSLLAAIARF
SLQTSARNQFFGTVLARGEEQVQQHLDILLADGKTTISALITQQSAERLQLQKGKEVLAL
IKAPWIDVYAATSNAPTADNVLSGKIQAIQHGVENSEILITLTGGETLCAMVPNALLEQQ
KLQQGADVKACFNADRVIIATLC